Effect of Calcium Salts on Swelling and Erosion of Xanthan Gum Matrix Systems

Chaw, Cheng and LikWok-Cheong, Vanessa Jade (2013) Effect of Calcium Salts on Swelling and Erosion of Xanthan Gum Matrix Systems. In: 2013 AAPS Annual Meeting and Exposition, 10-14 Nov 2013, Henry B Gonzalez Convention Centre, San Antonio.

Item Type:	Conference or Workshop Item (Poster)

Abstract

Purpose
Bivalent cations within the Xanthan gum (XG) matrix or in the dissolution medium affect the swelling and erosion profiles of
XG matrix system. This study aims to study the swelling and erosion behaviors of XG based cylindrical matrices loaded with
two different calcium salts.
Methods
XG based cylindrical matrices consisting of either calcium aminosalicylate (Ca4ASA) or calcium chloride (CaCl2), were
prepared using a single punch tableting machine. The ratios of Ca4ASA to XG were 1:5 and 1:3 while CaCl2 to XG were
~3:50 and ~3:20. The target weight of the matrices was adjusted to ~300mg. The swe
lling and erosion profiles of the matrices
were determined in pharmacopoeia buffer media adjusted to an ionic strength of 0.155M at pH values of 1.2 and 6.8. The
swelling index (SI) and erosion index (EI) of the matrices at the given time intervals were determined (up to 6 hours). For
each set of study, a plot of SI or EI vs.