Changes in mitochondrial function are pivotal in neurodegenerative and psychiatric disorders: How important is BDNF?

Markham, Anthony, Bains, R., Franklin, Paul and Spedding, M. (2014) Changes in mitochondrial function are pivotal in neurodegenerative and psychiatric disorders: How important is BDNF? British Journal of Pharmacology, 171 (8). pp. 2206-2229. ISSN 0007-1188

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Abstract

The brain is at the very limit of its energy supply and has evolved specific means of adapting function to energy supply, of which mitochondria form a crucial link. Neurotrophic and inflammatory processes may not only have opposite effects on neuroplasticity, but also involve opposite effects on mitochondrial oxidative phosphorylation and glycolytic processes, respectively, modulated by stress and glucocorticoids, which also have marked effects on mood. Neurodegenerative processes show marked disorders in oxidative metabolism in key brain areas, sometimes decades before symptoms appear (Parkinson’s and Alzheimer’s diseases). We argue that brain-derived neurotrophic factor couples activity to changes in respiratory efficiency
and these effects may be opposed by inflammatory cytokines, a key factor in neurodegenerative processes.

Item Type: Article
Subjects: Sciences > Biomedical Sciences
Sciences > Environment
Divisions: Faculty of Applied Sciences
Faculty of Applied Sciences > Department of Pharmacy Health and Wellbeing
Health Sciences and Wellbeing Beacon
Depositing User: Hannah Dodd
Date Deposited: 27 Aug 2014 09:16
Last Modified: 30 Sep 2017 10:05
URI: http://sure.sunderland.ac.uk/id/eprint/5071

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