Pharmacological and neuroprotective profile of an essential oil derived from leaves of Aloysia citrodora Palau

Abuhamdah, S, Abuhamdah, Rushdie, Howes, Melanie-Jayne R., Al-Olimat, Suleiman, Ennaceur, Abdelkader and Chazot, Paul (2015) Pharmacological and neuroprotective profile of an essential oil derived from leaves of Aloysia citrodora Palau. Journal of Pharmacy and Pharmacology, 67 (9). pp. 1306-1315. ISSN 2042-7158

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Abstract

Objectives
The Jordanian ‘Melissa’, (Aloysia citrodora) has been poorly studied both pharmacologically and in the clinic. Essential oils (EO) derived from leaves of A. citrodora were obtained by hydrodistillation, analysed by gas chromatography-mass spectrometry (GC-MS) and were investigated for a range of neurobiological and pharmacological properties, as a basis for potential future use in drug discovery.

Methods
A selection of central nervous system (CNS) receptor-binding profiles was carried out. Antioxidant activity and ferrous iron-chelating assays were adopted, and the neuroprotective properties of A. citrodora EO assessed using hydrogen peroxide-induced and Beta-amyloid-induced neurotoxicity with the CAD (Cath.-a-differentiated) neuroblastoma cell line.

Key findings
The major chemical components detected in the A. citrodora EOs, derived from dried and fresh leaves, included limonene, geranial, neral, 1, 8-cineole, curcumene, spathulenol and caryophyllene oxide, respectively. A. citrodora leaf EO inhibited [3H] nicotine binding to well washed rat forebrain membranes, and increased iron-chelation in vitro. A. citrodora EO displays effective antioxidant, radical-scavenging activities and significant protective properties vs both hydrogen peroxide- and Beta-amyloid-induced neurotoxicity.

Conclusions
A. citrodora EO displays a range of pharmacological properties worthy of further investigation to isolate the compounds responsible for the observed neuroactivities, to further analyse their mode of action and determine their clinical potential in neurodegenerative diseases.

Item Type: Article
Uncontrolled Keywords: Alzheimer’s disease; antioxidant; essential oils; neuroprotection
Subjects: Sciences > Biomedical Sciences
Psychology > Neuropsychology
Sciences > Pharmacy and Pharmacology
Divisions: Faculty of Applied Sciences
Faculty of Applied Sciences > Department of Pharmacy Health and Wellbeing
Related URLs:
Depositing User: Abdelkader Ennaceur
Date Deposited: 04 Feb 2016 14:12
Last Modified: 10 Oct 2017 12:34
URI: http://sure.sunderland.ac.uk/id/eprint/5865

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