Long-Term Cognitive Deficits After Subarachnoid Hemorrhage in Rats

Sasaki, Toshihiro, Hoffmann, Ulrike, Kobayashi, Motomu, Sheng, Huaxin, Ennaceur, Abdelkader, Lombard, Frederick W. and Warner, David S. (2016) Long-Term Cognitive Deficits After Subarachnoid Hemorrhage in Rats. Neurocritical Care. ISSN 1541-6933

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Abstract

Background
Cognitive dysfunction can be a long-term complication following subarachnoid hemorrhage (SAH). Preclinical models have been variously characterized to emulate this disorder. This study was designed to directly compare long-term cognitive deficits in the context of similar levels of insult severity in the cisterna magna double-blood (DB) injection versus prechiasmatic blood (PB) injection SAH models.

Methods
Pilot work identified blood injectate volumes necessary to provide similar mortality rates (20–25 %). Rats were then randomly assigned to DB or PB insults. Saline injection and naïve rats were used as controls. Functional and cognitive outcome was assessed over 35 days.

Results
DB and PB caused similar transient rotarod deficits. PB rats exhibited decreased anxiety behavior on the elevated plus maze, while anxiety was increased in DB. DB and PB caused differential deficits in the novel object recognition and novel object location tasks. Morris water maze performance was similarly altered in both models (decreased escape latency and increased swimming speed). SAH caused histologic damage in the medial prefrontal cortex, perirhinal cortex, and hippocampal CA1, although severity of injury in the respective regions differed between DB and PB.

Conclusion
Both SAH models caused long-term cognitive deficits in the context of similar insult severity. Cognitive deficits differed between the two models, as did distribution of histologic injury. Each model offers unique properties and both models may be useful for study of SAH-induced cognitive deficits.

Keywords
Subarachnoid hemorrhage – Cognitive dysfunction – Prechiasmatic blood injection model – Cisterna magna double blood injection model – Rat

Item Type: Article
Subjects: Sciences > Biomedical Sciences
Psychology > Cognitive Behaviour
Psychology > Neuropsychology
Sciences > Pharmacy and Pharmacology
Psychology > Psychology
Divisions: Faculty of Applied Sciences
Faculty of Applied Sciences > Department of Pharmacy Health and Wellbeing
Health Sciences and Wellbeing Beacon
Related URLs:
Depositing User: Abdelkader Ennaceur
Date Deposited: 31 Mar 2016 13:43
Last Modified: 09 Mar 2017 16:05
URI: http://sure.sunderland.ac.uk/id/eprint/5994

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