Pre-training in a radial arm maze abolished anxiety and impaired habituation in C57BL6/J mice treated with dizocilpine
Abuhamdah, R.M., Hussain, Muhammed, Paul, Chazot and Ennaceur, Abdelkader (2016) Pre-training in a radial arm maze abolished anxiety and impaired habituation in C57BL6/J mice treated with dizocilpine. Physiology and Behavior, 164. pp. 353-360. ISSN 0031-9384
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Abstract
Familiarity can imply a reduction of fear and anxiety, which may render learning and memory performance insensitive to NMDA receptor antagonism. Our previous study indicates that MK-801 (dizocilpine), NMDA antagonist, increased anxiety and prevented the acquisition of a spatial memory task. Here, we examined whether MK-801 will produce anxiety in mice that were familiar with the test environment.
Male C57BL/6J mice were exposed, one session a day for 7 days, to a 3D maze, which consisted of nine arms attached to upward inclined bridges radiating from a nonagonal platform. In this maze, high anxiety mice avoid the arms in the first sessions. One group of mice received saline (SAL) while a second group received MK-801 (MKD1), both on day one. A third group received saline in the first 3 sessions, and MK 801 in subsequent sessions (MKD4). Saline and MK-801 (0.1 mg/kg) were administered intraperitoneally 30 min before the test.
MKD4 mice demonstrated an increase in bridge and arm visits, and reached arm/bridge entries ratio close to 1 in session 5. SAL mice also crossed frequently onto the arms, and reached a comparable ratio, but this was achieved with a lower number of arm visits. MKD1 mice demonstrated a reduced number of arm visits in each session compared to SAL and MKD4 mice.
Dizocilpine produced anxiety in mice treated from day 1 of the test, but not in those treated from day 4. It also impaired habituation in animals familiar with the test environment; it produced sustained non-habituating hyperactivity.
Item Type: | Article |
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Uncontrolled Keywords: | Anxiety; NMDA; Learning; Familiarity; Habituation; Sensitization |
Subjects: | Sciences > Biomedical Sciences Psychology > Neuropsychology Sciences > Pharmacy and Pharmacology |
Divisions: | Faculty of Applied Sciences > Department of Pharmacy Health and Wellbeing Health Sciences and Wellbeing Beacon |
Depositing User: | Abdelkader Ennaceur |
Date Deposited: | 02 Aug 2016 15:16 |
Last Modified: | 22 Oct 2017 08:37 |
URI: | http://sure.sunderland.ac.uk/id/eprint/6440 |
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