Evaluation of the functionality of biodegradable polymeric platforms for drug delivery systems

Gioti, M., Karagkiozaki, V., Basgiouraki, A., Karagiannidis, Panagiotis and Logothetidis, S. (2013) Evaluation of the functionality of biodegradable polymeric platforms for drug delivery systems. Applied Surface Science, 281. pp. 54-59. ISSN 01694332

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Abstract

We present the development of a drug-loaded triple-layer platform consisting of thin film biodegradable polymers, in a properly designed form for the desired gradual degradation. Poly(dl-lactide-co-glycolide) (PLGA (65:35), PLGA (75:25)) and polycaprolactone (PCL) were grown by spin coating technique, to synthesize the platforms with the order PCL/PLGA (75:25)/PLGA (65:35) that determine their degradation rates. The outer PLGA (65:35) layer was loaded with dipyridamole, an antiplatelet drug. Spectroscopic ellipsometry (SE) in the Vis-far UV range was used to determine the nanostructure, as well as the content of the incorporated drug in the as-grown platforms. In situ and real-time SE measurements were carried out using a liquid cell for the dynamic evaluation of the fibrinogen and albumin protein adsorption processes. Atomic force microscopy studies justified the SE results concerning the nanopores formation in the polymeric platforms, and the dominant adsorption mechanisms of the proteins, which were defined by the drug incorporation in the platforms.

Item Type: Article
Depositing User: Panagiotis Karagiannidis
Date Deposited: 21 Sep 2017 15:24
Last Modified: 27 Sep 2017 13:36
URI: http://sure.sunderland.ac.uk/id/eprint/7765

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