Effect of piracetam on learned helplessness

Cavoy, Albert, Ennaceur, Abdelkader and Delacour, J (1988) Effect of piracetam on learned helplessness. Physiology & Behavior, 42 (6). pp. 545-549. ISSN 0031-9384

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Abstract

In rats, the effects of Piracetam (P), the prototype of nootropic drugs, were studied on a very widely used model of behavioral disturbance: the learned helplessness (LH) phenomenon. In this model, exposure to uncontrollable and unsignalled shocks impairs subsequent escape-avoidance learning. In a first experiment, this deficit was abolished by 200 mg/kg of P, and to a lesser extent, by a 100 mg/kg dose, administered before the training session. In non-stressed animals, no dose of P was able to have a facilitatory effect on escape-avoidance. In a second experiment, the administration of P, not before the training session as in Experiment I, but before the stress, had no effect on the LH phenomenon regardless of the dose.

Item Type: Article
Subjects: Sciences > Biomedical Sciences
Psychology > Neuropsychology
Sciences > Pharmacy and Pharmacology
Psychology
Sciences
Divisions: Faculty of Health Sciences and Wellbeing
Faculty of Applied Sciences > Department of Pharmacy Health and Wellbeing
Health Sciences and Wellbeing Beacon
Health Sciences and Wellbeing Beacon > Drug Discovery and Application Workstream
Related URLs:
Depositing User: Abdelkader Ennaceur
Date Deposited: 16 Oct 2017 10:50
Last Modified: 16 Oct 2017 10:50
URI: http://sure.sunderland.ac.uk/id/eprint/8100

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