Effects of physostigmine and scopolamine on rats' performances in object-recognition and radial-maze tests

Ennaceur, Abdelkader and Meliani, Kamel (1992) Effects of physostigmine and scopolamine on rats' performances in object-recognition and radial-maze tests. Psychopharmacology, 109 (3). pp. 321-330. ISSN 0033-3158

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Abstract

The effects of physostigmine and scopolamine were evaluated on working memory of rats in object recognition and radial-maze tests. Three doses of physostigmine hemi-sulfate (Phys: 0.05, 0.10 and 0.20 mg/kg), five doses of scopolamine hydrobromide (Scop: 0.125, 0.25, 0.5, 1.0 and 2.0 mg/kg), and one dose of scopolamine methylbromide (Mscop: 2.0 mg/kg) were used. In object recognition test, rats were submitted to three or four intertrial delay conditions (1-min, 15-min and either 60-min or 24-h). The higher doses of Scop (1.0 and 2.0 mg/kg) in 1-min and 15-min delay and of Phys (0.20 mg/kg) in 1-min delay impaired discrimination between new and familiar objects. Mscop impaired discrimination between objects in 60-min but not in 1-min and 15-min delay. This effect may be state dependent. Radial-maze learning was impaired by the lower doses of scopolamine (0.25 and 0.50 mg/kg) which had no effect in object recognition test. These results show that in our conditions, object recognition is less sensitive than radial-maze test to cholinergic drugs.

Item Type: Article
Subjects: Sciences > Biomedical Sciences
Psychology > Neuropsychology
Sciences > Pharmacy and Pharmacology
Psychology
Sciences
Divisions: Faculty of Health Sciences and Wellbeing
Faculty of Applied Sciences > Department of Pharmacy Health and Wellbeing
Health Sciences and Wellbeing Beacon
Health Sciences and Wellbeing Beacon > Drug Discovery and Application Workstream
Related URLs:
Depositing User: Abdelkader Ennaceur
Date Deposited: 17 Nov 2017 08:59
Last Modified: 16 Dec 2017 18:50
URI: http://sure.sunderland.ac.uk/id/eprint/8103

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