Abstract

Nano-sized barium-doped hydroxyapatite (n-BaHA) was successfully synthesized by a facile one-pot mechanochemical process. The effect of dopant loading on phase composition and morphological features as well as hexagonal lattice constants was assessed to study structural evolution of the milled particles. From the XRD-Rietveld refinement, thea- andc-axis directions and unit cell volume showed an increasing trend with the increase of the dopant content. From the TEM observations, the doped nanopowders were composed of nanospheroids with an average particle size of 36 ± 2 nm. This novel top-down approach provides an outline for the future design of nanostructured bioceramics.