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EZH2/KMT6A, G9A/EHMT2, GLP/EHMT1, differentiation, acute myeloid leukemia (AML), all-trans retinoic acid (ATRA), RARα, HKMTI-1-005
Dual inhibition of EZH2 and G9A/GLP histone methyltransferases by HKMTI-1-005 promotes differentiation of acute myeloid leukemia cells
Y. Sbirkov
T. Schenk
C. Kwok
S. Stengel
R. Brown
G. Brown
L. Chesler
A. Zelent
M. J. Fuchter
K. Petrie
All-trans-retinoic acid (ATRA)-based differentiation therapy of acute promyelocytic leukemia (APL) represents one of the most clinically effective examples of precision medicine and the first example of targeted oncoprotein degradation.
EZH2/KMT6AG9A/EHMT2GLP/EHMT1differentiationacute myeloid leukemia (AML)all-trans retinoic acid (ATRA)RARαHKMTI-1-005
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