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Adiponectin: Serum-saliva associations and relations with oral and systemic markers of inflammation

Riis, Jenna L, Bryce, Crystal I, Ha, Thao, Hand, Tracey, Stebbins, John L, Matin, Marla, Jaedicke, Katrin M and Granger, Douglas A (2017) Adiponectin: Serum-saliva associations and relations with oral and systemic markers of inflammation. Peptides, 91. pp. 58-64. ISSN 0196-9781

Item Type: Article

Abstract

This study addresses gaps in our understanding about the validity and utility of using salivary adiponectin to
index serum adiponectin levels. Matched blood and saliva samples were collected on a single occasion from
healthy adults (n=99; age 18–36 years, 53% male). Serum and saliva was assayed for adiponectin and
inflammatory cytokines (IL-1β, IL-6, IL-8, TNFα), and saliva was also assayed for markers of blood
contamination (transferrin), total protein (salivary flow rate) and matrix metalloproteinase-8 (MMP-8). We
examined the extent to which salivary adiponectin was associated with serum adiponectin, and the influence of
potential confounders on the serum-saliva correlation, including age, sex, body mass index, and markers of
inflammation, oral health, salivary blood contamination, and flow rate. Findings revealed a modest serum-saliva
association for adiponectin, and strong positive associations between salivary adiponectin and salivary levels of
inflammatory cytokines, MMP-8, transferrin, and total protein. By contrast, salivary adiponectin was not related
to serum levels of inflammatory activity. The magnitude of the serum-saliva association was strengthened when
controlling for total protein in saliva, blood leakage into oral fluid, salivary inflammatory cytokines, and MMP-8.
The pattern of findings extends our understanding of salivary adiponectin and its potential use as an index of
circulating adiponectin levels.

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More Information

Depositing User: Katrin Jaedicke

Identifiers

Item ID: 9091
Identification Number: https://doi.org/10.1016/j.peptides.2017.03.006
ISSN: 0196-9781
URI: http://sure.sunderland.ac.uk/id/eprint/9091
Official URL: https://www.sciencedirect.com/science/article/pii/...

Users with ORCIDS

ORCID for Katrin M Jaedicke: ORCID iD orcid.org/0000-0002-7389-5816

Catalogue record

Date Deposited: 15 May 2018 14:14
Last Modified: 20 May 2019 12:17

Contributors

Author: Katrin M Jaedicke ORCID iD
Author: Jenna L Riis
Author: Crystal I Bryce
Author: Thao Ha
Author: Tracey Hand
Author: John L Stebbins
Author: Marla Matin
Author: Douglas A Granger

University Divisions

Faculty of Health Sciences and Wellbeing

Subjects

Sciences > Health Sciences

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