High sensitivity of brain octopamine levels to stress

Ennaceur, Abdelkader, Coulon, JF, Delacour, Jean and David, Jean Claude (1986) High sensitivity of brain octopamine levels to stress. Psychopharmacology, 88 (3). pp. 305-309. ISSN 0033-3158

PDF (Octopamine in rodent model of depression)
High sensitivity of brain octopamine levels to stress.pdf - Published Version

Download (615kB) | Preview


Rats were submitted to unsignalled and uncontrolled electrical shocks. When re-exposed to the same situation but not shocked, 24 h later, their locomotor activity was significantly reduced compared to that of controls. This conditioned suppression was associated with a significant decrease in p-octopamine (OA) in brain stem and hypothalamus. Shocks delivered just before brain fixation produced an even larger decrease in cerebral OA. Heart levels of OA were not affected. Cerebral and peripheral levels of dopamine and noradrenaline were not significantly or reliably affected. These results, as those of previous experiments, suggest that octopamine is involved in emotional, neurovegetative responses to stress.

Item Type: Article
Subjects: Sciences > Biomedical Sciences
Psychology > Neuropsychology
Sciences > Pharmacy and Pharmacology
Divisions: Faculty of Health Sciences and Wellbeing
Faculty of Applied Sciences > Department of Pharmacy Health and Wellbeing
Health Sciences and Wellbeing Beacon
Health Sciences and Wellbeing Beacon > Drug Discovery and Application Workstream
Related URLs:
Depositing User: Abdelkader Ennaceur
Date Deposited: 13 Nov 2017 15:54
Last Modified: 14 Nov 2017 17:35
URI: http://sure.sunderland.ac.uk/id/eprint/8102

Actions (login required)

View Item View Item


Downloads per month over past year