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Effects of physostigmine and scopolamine on rats' performances in object-recognition and radial-maze tests

Ennaceur, Abdelkader and Meliani, Kamel (1992) Effects of physostigmine and scopolamine on rats' performances in object-recognition and radial-maze tests. Psychopharmacology, 109 (3). pp. 321-330. ISSN 0033-3158

Item Type: Article

Abstract

The effects of physostigmine and scopolamine were evaluated on working memory of rats in object recognition and radial-maze tests. Three doses of physostigmine hemi-sulfate (Phys: 0.05, 0.10 and 0.20 mg/kg), five doses of scopolamine hydrobromide (Scop: 0.125, 0.25, 0.5, 1.0 and 2.0 mg/kg), and one dose of scopolamine methylbromide (Mscop: 2.0 mg/kg) were used. In object recognition test, rats were submitted to three or four intertrial delay conditions (1-min, 15-min and either 60-min or 24-h). The higher doses of Scop (1.0 and 2.0 mg/kg) in 1-min and 15-min delay and of Phys (0.20 mg/kg) in 1-min delay impaired discrimination between new and familiar objects. Mscop impaired discrimination between objects in 60-min but not in 1-min and 15-min delay. This effect may be state dependent. Radial-maze learning was impaired by the lower doses of scopolamine (0.25 and 0.50 mg/kg) which had no effect in object recognition test. These results show that in our conditions, object recognition is less sensitive than radial-maze test to cholinergic drugs.

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Depositing User: Abdelkader Ennaceur

Identifiers

Item ID: 8103
Identification Number: https://doi.org/10.1007/BF02245880
ISSN: 0033-3158
URI: http://sure.sunderland.ac.uk/id/eprint/8103
Official URL: https://link.springer.com/article/10.1007/BF022458...

Users with ORCIDS

ORCID for Abdelkader Ennaceur: ORCID iD orcid.org/0000-0001-6398-4383

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Date Deposited: 17 Nov 2017 08:59
Last Modified: 18 Dec 2019 15:41