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Increased adverse events following third dose of BNT162b2/Pfizer vaccine in those with previous COVID-19, but not with concurrent influenza vaccine

Raw, Rachael K., Rees, Jon and Chadwick, David R. (2023) Increased adverse events following third dose of BNT162b2/Pfizer vaccine in those with previous COVID-19, but not with concurrent influenza vaccine. PLOS Global Public Health, 3 (2). e0001053. ISSN 2767-3375

Item Type: Article

Abstract

Prior studies suggest that adverse events (AEs) following doses one and two of BNT162b2/Pfizer vaccine are worse in those with a prior history of COVID-19. To establish whether this outcome applies to a third/booster dose, we conducted a survey with 534 healthcare workers (HCW) in Northeast England, who reported AEs following all three doses of BNT162b2/Pfizer vaccine. We also explored AEs associated with concurrent seasonal influenza immunisation, in a subset of 492 HCWs. For all doses of BNT162b2/Pfizer vaccine there was a cluster of systemic AEs that were consistently worse in HCWs with a prior history of COVID-19. AEs were no worse in HCWs who received their third/booster dose within 7 days of the influenza jab, rather than further apart. Gender and the presence of ongoing COVID-19 symptoms (OCS) had no effect on AEs associated with COVID-19 or influenza vaccination, though younger HCWs experienced more AEs overall. Our findings have implications for vaccine hesitancy and immunisation protocols.

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More Information

Uncontrolled Keywords: SARS-CoV-2; COVID-19; COVID-19 Vaccination; Vaccine-Associated Adverse Events; Long-COVID; Vaccine Hesitancy; Influenza; Influenza Vaccination.
Depositing User: Jon Rees

Identifiers

Item ID: 15760
Identification Number: https://doi.org/10.1371/journal.pgph.0001053
ISSN: 2767-3375
URI: http://sure.sunderland.ac.uk/id/eprint/15760
Official URL: https://dx.plos.org/10.1371/journal.pgph.0001053

Users with ORCIDS

ORCID for Jon Rees: ORCID iD orcid.org/0000-0002-3295-244X

Catalogue record

Date Deposited: 15 May 2023 10:32
Last Modified: 15 May 2023 10:32

Contributors

Author: Jon Rees ORCID iD
Author: Rachael K. Raw
Author: David R. Chadwick

University Divisions

Faculty of Health Sciences and Wellbeing > School of Psychology

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