Abstract

Objective: Air pollution can contribute to the development and worsening of respira�tory health problems. This study was conducted to study the effect of PM10 and NOx on
COPD and asthma patients because the effect of PM10 and NOx on COPD and asthma
patients has not been well studied in Nigeria. We investigated the effect of PM10 and
NOx on registered COPD and asthma patients in two government-owned hospitals in
Abuja Nigeria. Methods: Data were collected on monthly FVC, FEV1, using spirobank
and dyspnoea with MRC dyspnoea scale from a study sample of 402 hospital-recruited
COPD or asthma patients for 16 months. Routine air quality monitoring data and me�teorological data were collated over the same time period. Correlation and multiple
regression analyses were performed to calculate the correlation between respiratory
disease (COPD and asthma) and the pollutants (PM10, NOx) concentration. Results:
The 24-hour mean of PM10 in the study was 296.7µg/m3
, and the NO2 1-hour mean was
253.1µg/m3
, which are both higher than the WHO guidelines. The PM10 increase was
significantly associated with decreased FEV1 and FVC in the participants (-786,
P=.000); with a moderate significant association between NOx and FVC (-.582,
P= .018). A significant association was also observed between PM10 with Dyspnoea
(-.786, P=.000). When we stratified for gender, it was observed that women had a
higher significance P= .001. Conclusions: The observed consistency of the adverse
health effects of PM10 across the tested variables and the health outcomes and diseases
supports policy measures to control PM10 and NOx. This study provides evidence that
exposure to ambient air pollution has adverse effects on lung function in adults.