The role of palliative radiotherapy for haemostasis in unresectable gastric cancer: a single-institution experience

Chaw, Cheng, Niblock, P, Chaw, C S and Adamson, D J (2014) The role of palliative radiotherapy for haemostasis in unresectable gastric cancer: a single-institution experience. Ecancermedical science, 8 (384). ISSN 1754-6605

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Abstract

Purpose: To evaluate the outcomes of patients with gastric cancer bleeding who had been treated with palliative radiotherapy with haemostatic intent.

Methods and materials: Fifty-two gastric cancer patients aged 52–92 years (median 78 years) with active bleeding or anaemia resulting from inoperable gastric cancer were treated with short-course radiotherapy. Responses to radiotherapy treatment were evaluated based on the changes of haemoglobin level, number of transfusions received before and after radiotherapy, and overall median survival.

Results: Thirty-nine (75%) patients received single 8 Gy fraction, and 13 (25%) patients received 20 Gy in five daily fractions. The need for transfusion was evaluable in 44 patients, and the response rate was 50%, with less requirement for blood transfusions within four weeks of radiotherapy. There was also an increase in mean haemoglobin level (0.66 ± 1.12 g/dl, p < 0.01) after radiotherapy in 35 evaluable patients. The overall median survival (calculated from last day of treatment to date of death) was 160 days (95% CI of 119–201 days), making actuarial 12-month survival 15%.

Conclusion: Palliative short-course radiotherapy is a reasonably effective treatment that can provide durable palliation of bleeding in gastric cancer.

Keywords: bleeding, gastric cancer, haemostasis, palliative, radiotherapy

Item Type: Article
Subjects: Sciences > Pharmacy and Pharmacology
Divisions: Faculty of Applied Sciences > Department of Pharmacy Health and Wellbeing
Related URLs:
Depositing User: Barry Hall
Date Deposited: 30 Sep 2015 08:44
Last Modified: 09 Mar 2017 10:19
URI: http://sure.sunderland.ac.uk/id/eprint/5755

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