Elevated Expression of LGR5 and WNT Signaling Factors in Neuroblastoma Cells With Acquired Drug Resistance
Myssina, Svetlana, Clark-Corrigall, John, Michaelis, Martin, Cinatl, Jindrich, Ahmed, Shafiq and Carr-Wilkinson, Jane (2022) Elevated Expression of LGR5 and WNT Signaling Factors in Neuroblastoma Cells With Acquired Drug Resistance. Cancer Investigation, 41 (2). pp. 173-182. ISSN 0735-7907
| Item Type: | Article |
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Abstract
Neuroblastoma (NB) is a paediatric solid cancer with high fatality, relapses and acquired resistance to chemotherapy that requires new therapeutic approaches to improve survival.
LGR5 is a receptor that potentiates WNT/ signalling pathway and has been reported to promote development and survival in several adult cancers.
In this study we investigated LGR5 expression in a panel of NB cell lines with acquired resistance to vincristine or doxorubicin.
We show LGR5-LRP6 cooperation with enhanced expression in drug resistant NB cell lines compared to parental cells, suggesting a role for LGR5 in the emergence of drug resistance, warranting further investigation
Key words: LGR5, LRP6, WNT pathway, neuroblastoma, acquired drug resistance.
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PDF (Accepted version of manuscript)
449785v2.full JCW 171022.pdf - Accepted Version Available under License Creative Commons Attribution Non-commercial No Derivatives. Download (1MB) | Preview |
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| Depositing User: Jane Carr-Wilkinson |
Identifiers
| Item ID: 16189 |
| Identification Number: https://doi.org/10.1080/07357907.2022.2136682 |
| ISSN: 0735-7907 |
| URI: http://sure.sunderland.ac.uk/id/eprint/16189 | Official URL: http://dx.doi.org/10.1080/07357907.2022.2136682 |
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| Date Deposited: 01 Jun 2023 16:20 |
| Last Modified: 06 Nov 2023 03:38 |
| Author: | Svetlana Myssina |
| Author: | John Clark-Corrigall |
| Author: | Martin Michaelis |
| Author: | Jindrich Cinatl |
| Author: | Shafiq Ahmed |
| Author: | Jane Carr-Wilkinson |
University Divisions
Faculty of Health Sciences and Wellbeing > School of MedicineSubjects
Sciences > Biomedical SciencesSciences
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