Chromogenic enzyme substrates based on [2-(nitroaryl)ethenyl]pyridinium and quinolinium derivatives for the detection of nitroreductase activity in clinically important microorganisms†
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Cellier-Rastit, Marie, Chalansonnet, Valerie, James, Arthur L, Johnston, Annette, Orenga, Sylvain, Perry, John D., Roger-Dalbert, Celine, Salwatura, Vindhya L, Stanforth, Stephen P, Sykes, Hannah E and Truong, Viet T (2023) Chromogenic enzyme substrates based on [2-(nitroaryl)ethenyl]pyridinium and quinolinium derivatives for the detection of nitroreductase activity in clinically important microorganisms†. Journal of Materials Chemistry B, 11. pp. 6106-6113. ISSN 2050-7518
| Item Type: | Article |
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Abstract
A series of [2-(nitroaryl)ethenyl]pyridinium and quinolinium derivatives have been synthesised as potential indicators of microbial nitroreductase activity. When assessed against a selection of 20 clinically important pathogenic microorganisms, microbial colonies of various colours (yellow, green, red, brown, black) were produced and attributed to nitroreductase activity. Most substrates elicited colour responses with Gram-negative microorganisms. In contrast, the growth of several species of Gram-positive microorganisms and yeasts was often inhibited by the substrates and hence coloured responses were not seen.
Graphical abstract: Chromogenic enzyme substrates based on [2-(nitroaryl)ethenyl]pyridinium and quinolinium derivatives for the detection of nitroreductase activity in clinically important microorganisms
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| Depositing User: Thang Truong |
Identifiers
| Item ID: 16449 |
| Identification Number: https://doi.org/10.1039/d3tb00715d |
| ISSN: 2050-7518 |
| URI: http://sure.sunderland.ac.uk/id/eprint/16449 | Official URL: https://pubs.rsc.org/en/content/articlelanding/202... |
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Catalogue record
| Date Deposited: 31 Jul 2023 09:49 |
| Last Modified: 31 Jul 2023 09:49 |
| Author: |
Viet T Truong
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| Author: | Marie Cellier-Rastit |
| Author: | Valerie Chalansonnet |
| Author: | Arthur L James |
| Author: | Annette Johnston |
| Author: | Sylvain Orenga |
| Author: | John D. Perry |
| Author: | Celine Roger-Dalbert |
| Author: | Vindhya L Salwatura |
| Author: | Stephen P Stanforth |
| Author: | Hannah E Sykes |
University Divisions
Faculty of Health Sciences and Wellbeing > School of Pharmacy and Pharmaceutical SciencesSubjects
Sciences > ChemistrySciences > Health Sciences
Sciences > Pharmacy and Pharmacology
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Chromogenic enzyme substrates based on [2-(nitroaryl)ethenyl]pyridinium and quinolinium derivatives for the detection of nitroreductase activity in clinically important microorganisms†. (deposited 26 Jun 2023 15:58)
- Chromogenic enzyme substrates based on [2-(nitroaryl)ethenyl]pyridinium and quinolinium derivatives for the detection of nitroreductase activity in clinically important microorganisms†. (deposited 31 Jul 2023 09:49) [Currently Displayed]
