Modern manufacturing organizations are designing, building and operating large, complex and often ‘one of a kind’ assets, which incorporate many different electrical, electronic, hydraulic and mechanical systems and components. Due to this complexity and the need to react quickly to changes in production, there is a need for more advanced strategies to ensure effective and efficient high maintenance and high availability. Modern maintenance strategies including Total Productive Maintenance and Reliability Centred Maintenance (RCM) have proven successful. With the increase in complexity and a large number of interconnected components, however, the use of one single strategy may not provide the necessary detailed system to support a maintenance task selection. The paper will propose that for complex assets with a large number of systems, a new framework will be proposed utilising RCM, and include additional supporting systems, including Value Stream Mapping and Cost Benefit Analysis.