Fabrication and physicochemical characterisation of novel pimozide loaded PLGA nanoparticles

Uddin, Nazim, Elkordy, Amal and Faheem, Ahmed (2019) Fabrication and physicochemical characterisation of novel pimozide loaded PLGA nanoparticles. British Journal of Pharmacy, 4 (1). pp. 22-23. ISSN 2058-8356

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Abstract

Cancer has always been a big concern for human health. There is always an increased need for fabrication of newer drugs or repurposing existing drugs to treat cancer. Apart from being an antipsychotic agent, pimozide has already shown its anticancer activity against various cancers in several studies. The aim of the present study was to fabricate pimozide loaded PLGA nanoparticles and characterise them. Single emulsion and microfluidic techniques were used to prepare nanoparticles. Physicochemical properties such as particle size, shape, surface charge and encapsulation efficiency were investigated. Results showed that the nanoparticles had an average size distribution of 200-300 nm, were spherical in shape and negatively charged. Additionally, a high encapsulation efficiency (50-89%) makes these nanoparticles potential drug delivery systems to target cancer cells.

Item Type: Article
Divisions: Faculty of Health Sciences and Wellbeing
Depositing User: Klaire Purvis
Date Deposited: 03 May 2019 12:39
Last Modified: 20 May 2019 11:18
URI: http://sure.sunderland.ac.uk/id/eprint/10725

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