Synovial cell metabolism and chronic inflammation in rheumatoid arthritis

Falconer, Jane, Murphy, AN, Young, SP, Clark, AR, Tiziani, S, Guma, M and Buckley, CD (2018) Synovial cell metabolism and chronic inflammation in rheumatoid arthritis. Arthritis and Rheumatology, 70 (7). pp. 984-999. ISSN 2326-5205

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Official URL: 10.1002/art.40504

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Abstract

Metabolomic studies of body fluids show that immune-mediated inflammatory diseases such as rheumatoid arthritis (RA) are associated with metabolic disruption. This is likely to reflect the increased bioenergetic and biosynthetic demands of sustained inflammation and changes to nutrient and oxygen availability in damaged tissue. The synovial membrane lining layer is the principle site of inflammation in RA. Here the resident cells are the fibroblast-like synoviocytes (FLS) and the synovial tissue macrophages (STM), which are transformed toward overproduction of enzymes which degrade cartilage and bone, and cytokines which promote immune cell infiltration. Recent studies have shown metabolic changes in both FLS and macrophages from RA patients and these may be therapeutically targetable. However, as the origins and subset specific functions of synoviocytes are poorly understood and the signaling modules which control metabolic deviation in RA synovial cells are yet to be explored, significant additional research is needed to translate these findings toward clinical application. Furthermore, in many inflamed tissues, different cell types can forge metabolic collaborations through solute carriers (SLC) in their membranes, to meet a high demand for energy or biomolecules. Such relationships are likely to exist in the synovium and are yet to be explored. Finally, it is not yet known whether metabolic change is a consequence of disease or if primary changes to cellular metabolism might underlie or contribute to early stage disease pathogenesis. This article collates what is known about metabolism in synovial tissue cells and highlights future research directions in this area.

Item Type: Article
Divisions: Faculty of Health Sciences and Wellbeing > School of Medicine
Depositing User: Jane Falconer
Date Deposited: 06 Sep 2019 13:44
Last Modified: 06 Sep 2019 13:44
URI: http://sure.sunderland.ac.uk/id/eprint/11081
ORCID for Jane Falconer: ORCID iD orcid.org/0000-0002-6601-7919

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