Desolvation Conditions for Production of Sulfasalazine Based Albumin Nanoparticles: Physical Properties

Chaw, Cheng and Olaitan, Victor (2019) Desolvation Conditions for Production of Sulfasalazine Based Albumin Nanoparticles: Physical Properties. Pharmaceutical Frontiers. ISSN 2633-1195

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Abstract

Background: Albumin-based nanoparticles have been used as drug carriers to improve therapeutic effect. This study aimed to produce sulfasalazine (SSZ)-loaded bovine serum albumin (BSA) nanoparticles by desolvation technique and characterize their physical properties. Drug loading effect was also investigated.

Methods: SSZ albumin nanoparticles were batch produced by desolvation technique and lyophilized. Physical characteristics of nanoparticles including size distribution, zeta potential and entrapment efficiency were studied.

Results: Nanoparticles were spherical and typically 200–400 nm with low polydispersity (PDI). The zeta potentials of nanoparticles ranged from −21 to −41 mV, which were attributed to BSA and SSZ. The highest actual drug loading was close to 0.5%w/w. The addition of 2% sucrose during lyophilization was essential to avoid cake collapse and the particle sizes increased slightly where their PDI values were low. Although the presence of sucrose led to a slight reduction in zeta potential, it had limited effect on zeta potential of the nanoparticles. The interactions between SSZ and formulation excipients were also confirmed with FTIR and DSC analyses.

Conclusion: Desolvation technique produced stable sulfasalazine-loaded nanoparticles that can be administered parenterally.

KEYWORDS: sulfasalazine; nanoparticle; albumin; physical property

Item Type: Article
Divisions: Faculty of Health Sciences and Wellbeing
Faculty of Health Sciences and Wellbeing > School of Pharmacy and Pharmaceutical Sciences
Depositing User: Klaire Purvis-Shepherd
Date Deposited: 25 Sep 2019 09:37
Last Modified: 18 Dec 2019 16:08
URI: http://sure.sunderland.ac.uk/id/eprint/11135
ORCID for Cheng Chaw: ORCID iD orcid.org/0000-0002-7450-4100

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