The article examines the entrepreneurial decision-making in the Greek tourism and hospitality sector, during a period of an economic crisis. The nationwide study includes the responses of 503 entrepreneurs engaged in the Greek travel,
tourism and hospitality industry. The research employs fuzzy-set Qualitative Comparative Analysis (fsQCA), and examines trust, enterprising negotiation power, tourism decision-making considerations, and crisis effects. It also includes the categorical data of operational mode and
company type. The analysis has generated three different pathways for entrepreneurial decision-making during crisis in the Greek tourism and hospitality sector. Those pathways are: (i) crisis conditions (ii) enterprising operations and focus, and (iii) enterprising capabilities. Due to the limited employment of fsQCA in the tourism sector, its full potential is still to be explored. The study provides three different pathways that Greek tourism entrepreneurs select for their decision-making, according to the characteristics of their firms and their market orientation. CUST_SOCIAL_IMPLICATIONS_(LIMIT_100_WORDS) :No data available. Theoretically the study contributes by enhancing understanding of entrepreneurial decision-making during periods of crisis. In the methodological domain the research employs fsQCA, which has only recently started to be used in tourism and hospitality, and generally the service sector.