Accuracy of Peripheral Arterial Disease Registers in UK General Practice: Case-Control Study

Kyle, Daniel, Boylan, Luke, Wilson, Lesley, Haining, Shona, Oates, Crispian, Sims, Andrew, Guri, Ina, Allen, John, Wilkes, Scott and Stansby, Gerry (2020) Accuracy of Peripheral Arterial Disease Registers in UK General Practice: Case-Control Study. Journal of Primary Care & Community Health, 11. p. 2150132720946148. ISSN 2150-1327

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Abstract

Background:: Approximately 20% of the UK population aged 55 to 75 years have evidence of peripheral arterial disease (PAD). PAD affects quality of life and life expectancy if not appropriately diagnosed and managed. At risk patients require accurate diagnosis to ensure optimal treatment to slow disease progression and minimize adverse outcomes. Aim:: To assess the accuracy of general practice (GP) registration of the diagnosis of peripheral arterial disease (PAD). Design and Setting:: An observational analytic case-control study. As part of a National Institute for Health Research–funded (ISRCTN13301188) project assessing novel diagnostic methods set in GP practice. Methods:: A total of 125 patients registered as having PAD and 125 age- and sex-matched controls were recruited from 15 general practices across North East England. The register was then assessed for accuracy of diagnosis. Duplex vascular ultrasound scanning (DUS) undertaken by vascular scientists was used as the gold standard reference for PAD. Results:: The PAD register had a sensitivity of 86% (95% CI 77%-92%) and specificity of 74% (95% CI 67%-81%) when compared with DUS. The positive predictive value, however, was 69.6% (95% CI 63%-75%) and negative predictive value 88.8% (95% CI 82%-92%). The overall diagnostic effectiveness of the PAD register was 79.2% (95% CI 73%-84%). Conclusion:: This analysis indicates that while PAD is detected with reasonable sensitivity in primary care, many patients registered with a diagnosis of PAD lacked DUS-proven disease. Improved approaches to the objective diagnosis of PAD may improve diagnosis and management of PAD in primary care.

Item Type: Article
Additional Information: ** Embargo end date: 22-09-2020 ** From SAGE Publishing via Jisc Publications Router ** History: received 21-05-2020; rev-recd 03-07-2020; accepted 04-07-2020; epub 22-09-2020. ** Licence for this article starting on 22-09-2020: https://creativecommons.org/licenses/by/4.0/
Uncontrolled Keywords: Original Research, Peripheral arterial disease, screening, primary care, duplex ultrasound scanning
Divisions: Faculty of Health Sciences and Wellbeing > School of Nursing and Health Sciences
Related URLs:
SWORD Depositor: Publication Router
Depositing User: Publication Router
Date Deposited: 04 Nov 2020 13:45
Last Modified: 04 Nov 2020 13:45
URI: http://sure.sunderland.ac.uk/id/eprint/12628
ORCID for Luke Boylan: ORCID iD orcid.org/0000-0003-1577-8221
ORCID for Scott Wilkes: ORCID iD orcid.org/0000-0003-2949-7711

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