The Application of Gene Expression Profiling in Predictions of Occult Lymph Node Metastasis in Colorectal Cancer Patients

Peyravian, Noshad, Larki, Pegah, Gharib, Ehsan, Nazemalhosseini-Mojarad, Ehsan, Anaraki, Fakhrosadate, Young, Chris, McClellan, James, Ashrafian Bonab, Maziar, Asadzadeh-Aghdaei, Hamid and Zali, Mohammad (2018) The Application of Gene Expression Profiling in Predictions of Occult Lymph Node Metastasis in Colorectal Cancer Patients. Biomedicines, 6 (1). p. 27. ISSN 2227-9059

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Abstract

A key factor in determining the likely outcome for a patient with colorectal cancer is whether or not the tumour has metastasised to the lymph nodes-information which is also important in assessing any possibilities of lymph node resection so as to improve survival. In this review we perform a wide-range assessment of literature relating to recent developments in gene expression profiling (GEP) of the primary tumour, to determine their utility in assessing node status. A set of characteristic genes seems to be involved in the prediction of lymph node metastasis (LNM) in colorectal patients. Hence, GEP is applicable in personalised/individualised/tailored therapies and provides insights into developing novel therapeutic targets. Not only is GEP useful in prediction of LNM, but it also allows classification based on differences such as sample size, target gene expression, and examination method.

Item Type: Article
Divisions: Faculty of Health Sciences and Wellbeing > School of Nursing and Health Sciences
Depositing User: Leah Maughan
Date Deposited: 04 Jan 2021 17:17
Last Modified: 04 Jan 2021 17:30
URI: http://sure.sunderland.ac.uk/id/eprint/12938
ORCID for Maziar Ashrafian Bonab: ORCID iD orcid.org/0000-0002-9833-7976

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