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Simulated games activity vs continuous running exercise: A novel comparison of the glycemic and metabolic responses in T1DM patients

Campbell, Matthew, West, D. J., Bain, S. C., Kingsley, M. I. C., Foley, P., Kilduff, L., Turner, D., Gray, B., Stephens, J. W. and Bracken, R. M. (2014) Simulated games activity vs continuous running exercise: A novel comparison of the glycemic and metabolic responses in T1DM patients. Scandinavian Journal of Medicine & Science in Sports, 25 (2). pp. 216-222. ISSN 0905-7188

Item Type: Article


To compare the glycemic and metabolic responses to simulated intermittent games activity and continuous running exercise in type 1 diabetes. Nine patients (seven male, two female; 35 ± 4 years; HbA1c 8.1 ± 0.2%/65 ± 2 mmol/mol) treated on a basal‐bolus regimen completed two main trials, a continuous treadmill run (CON) or an intermittent running protocol (INT). Patients arrived to the laboratory fasted at ∼ 08:00 h, replicating their usual pre‐exercise meal and administering a 50% reduced dose of rapid‐acting insulin before exercising. Blood glucose (BG), K+, Na++, pH, triglycerides, serum cortisol and NEFA were measured at baseline and for 60 min post‐exercise. Interstitial glucose was measured for a further 23 h under free‐living conditions. Following exercise, BG declined under both conditions but was less under INT (INT −1.1 ± 1.4 vs CON −5.3 ± 0.4 mmol/L, P = 0.037), meaning more patients experienced hypoglycemia (BG ≤ 3.5 mmol/L; CON n = 3 vs INT n = 2) but less hyperglycemia (BG ≥ 10.9 mmol/L; CON n = 0 vs INT n = 6) under CON. Blood lactate was significantly greater, and pH lower, with a temporal delay in K+ under INT (P < 0.05). No conditional differences were observed in other measures during this time, or in interstitial glucose concentrations during the remaining 23 h after exercise. Simulated games activity carries a lower risk of early, but not late‐onset hypoglycemia than continuous running exercise in type 1 diabetes.

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Depositing User: Leah Maughan


Item ID: 13028
Identification Number:
ISSN: 0905-7188
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ORCID for Matthew Campbell: ORCID iD

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Date Deposited: 28 Jan 2021 14:43
Last Modified: 28 Jan 2021 14:43


Author: Matthew Campbell ORCID iD
Author: D. J. West
Author: S. C. Bain
Author: M. I. C. Kingsley
Author: P. Foley
Author: L. Kilduff
Author: D. Turner
Author: B. Gray
Author: J. W. Stephens
Author: R. M. Bracken

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Faculty of Health Sciences and Wellbeing > School of Nursing and Health Sciences

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