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Sunderland Repository records the research produced by the University of Sunderland including practice-based research and theses.

Reductions in resistance exercise-induced hyperglycaemic episodes are associated with circulating interleukin-6 in Type 1 diabetes

Turner, D., Luzio, S., Kilduff, L. P., Gray, B. J., Dunseath, G., Bain, S. C., Campbell, Matthew, West, D. J. and Bracken, R. M. (2014) Reductions in resistance exercise-induced hyperglycaemic episodes are associated with circulating interleukin-6 in Type 1 diabetes. Diabetic Medicine, 31 (8). pp. 1009-1013. ISSN 0742-3071

Item Type: Article


To determine the influence of different volumes of resistance exercise on circulating interleukin‐6 (IL‐6) and to explore the relationships between IL‐6 and glycaemia.

Eight participants with complication‐free Type 1 diabetes, whose mean ± sem age was 38 (6) years, mean ± sem HbA1c concentration was 71 ±11 mmol/mol (8.7 ±1.0%) and mean ± sem Type 1 diabetes duration was 15 ±13 years, attended the research facility after an overnight fast on four separate occasions, having administered their basal insulin the night before (glargine 27.5±3.1U, n=8), but omitted morning rapid‐acting insulin. Participants completed either a one‐set (14‐min), two‐set (28‐min), or three‐set (42‐min) resistance exercise trial (eight exercises × 10 repetitions) at 67±3% one‐repetition maximum followed by a 60‐min recovery, or a resting control trial. Venous blood samples were taken before and after exercise. Data were analysed using repeated‐measures anova (P≤0.05).

Whereas IL‐6 levels remained similar to baseline levels after one set of resistance exercises (30 min, P=0.287; 60 min, P=0.318), IL‐6 levels were > baseline levels at 60 min post‐exercise after a two‐set exercise trial (2.94 ± 0.94 pg/ml, P=0.002) and doubled at both 30 min (4.01 ± 1.00 pg/ml, P=0.048) and 60 min (4.28 ± 1.25 pg/ml, P=0.084) post‐exercise after the three‐set resistance exercise trial. Post‐exercise blood glucose area under the curve (mmol/l/60 min) was greater after both the one‐set (P=0.025) and two‐set trials (P=0.008), than after the control trial, but similar between the three‐set trial and the control trial (P=0.240). The rise in IL‐6 from baseline to peak concentration significantly correlated inversely with blood glucose area under the curve (r=‐0.65, P=0.041).

Circulating IL‐6 is increased by resistance exercise in a volume‐dependent manner, and resistance exercise‐induced increases in IL‐6 correlated with reductions in post‐exercise hyperglycaemia in Type 1 diabetes, suggesting a role for IL‐6 in improving post‐resistance exercise glycaemic disturbances in Type 1 diabetes.

(Clinical Trials Registry No: ISRCTN60407046)

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Depositing User: Leah Maughan


Item ID: 13031
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ISSN: 0742-3071
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Users with ORCIDS

ORCID for Matthew Campbell: ORCID iD

Catalogue record

Date Deposited: 28 Jan 2021 15:25
Last Modified: 28 Jan 2021 15:25


Author: Matthew Campbell ORCID iD
Author: D. Turner
Author: S. Luzio
Author: L. P. Kilduff
Author: B. J. Gray
Author: G. Dunseath
Author: S. C. Bain
Author: D. J. West
Author: R. M. Bracken

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Faculty of Health Sciences and Wellbeing > School of Nursing and Health Sciences

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