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Multiple pregnancy rate in patients undergoing treatment with clomifene citrate for WHO group II ovulatory disorders: a systematic review

Garthwaite, Heather, Stewart, Jane and Wilkes, Scott (2021) Multiple pregnancy rate in patients undergoing treatment with clomifene citrate for WHO group II ovulatory disorders: a systematic review. Human Fertility. pp. 1-10. ISSN 1742-8149

Item Type: Article


Clomifene citrate has long been associated with a multiple pregnancy rate of up to 8–10%. Studies from which these figures originated have largely included patients who received clomifene outside of current national and international treatment guidelines. In January 2020, a systematic review of MEDLINE and relevant reference lists was conducted. Studies were included that reported multiple pregnancy rate in a cohort of patients undergoing treatment with single agent clomifene citrate for WHO group II dysovulatory subfertility. Twelve studies were included in the analysis, with a total sample size of 1,387 patients. The overall multiple pregnancy rate was 3.8% (3.6% twins/0.2% triplets); this dropped to 2.4% (all twins) when studies with a mean BMI ≥35kg/m2 were excluded. This review suggests that contemporary single agent clomifene use following current guidelines in terms of indication, results in a lower than expected multiple pregnancy rate. Further evidence from clinical practice is required to ensure that patients are adequately informed.

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Additional Information: ** From Crossref journal articles via Jisc Publications Router ** History: epub 15-01-2021; issued 15-01-2021.
Uncontrolled Keywords: Obstetrics and Gynaecology, Reproductive Medicine, General Medicine
SWORD Depositor: Publication Router
Depositing User: Publication Router


Item ID: 13086
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ISSN: 1742-8149
Official URL:

Users with ORCIDS

ORCID for Heather Garthwaite: ORCID iD
ORCID for Scott Wilkes: ORCID iD

Catalogue record

Date Deposited: 01 Feb 2021 11:46
Last Modified: 16 Nov 2021 03:38


Author: Heather Garthwaite ORCID iD
Author: Scott Wilkes ORCID iD
Author: Jane Stewart

University Divisions

Faculty of Health Sciences and Wellbeing > School of Nursing and Health Sciences

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