Genome-wide association study identifies risk loci for progressive chronic lymphocytic leukemia

Lin, Wei-Yu, Fordham, Sarah E., Sunter, Nicola, Elstob, Claire, Rahman, Thahira, Willmore, Elaine, Shepherd, Colin, Strathdee, Gordon, Mainou-Fowler, Tryfonia, Piddock, Rachel, Mearns, Hannah, Barrow, Timothy, Houlston, Richard S., Marr, Helen, Wallis, Jonathan P, Summerfield, Geoffrey, Marshall, Scott, Pettitt, Andrew, Pepper, Christopher, Fegan, Christopher, Forconi, Francesco, Dyer, Martin J. S., Jayne, Sandrine, Sellors, April, Schuh, Anna, Robbe, Pauline, Oscier, David, Bailey, James, Rais, Syed, Bentley, Alison, Cawkwell, Lynn, Evans, Paul, Hillmen, Peter, Pratt, Guy, Allsup, David J. and Allan, James M. (2021) Genome-wide association study identifies risk loci for progressive chronic lymphocytic leukemia. Nature Communications, 12 (1). p. 665. ISSN 2041-1723

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Abstract

Abstract: Prognostication in patients with chronic lymphocytic leukemia (CLL) is challenging due to heterogeneity in clinical course. We hypothesize that constitutional genetic variation affects disease progression and could aid prognostication. Pooling data from seven studies incorporating 842 cases identifies two genomic locations associated with time from diagnosis to treatment, including 10q26.13 (rs736456, hazard ratio (HR) = 1.78, 95% confidence interval (CI) = 1.47–2.15; P = 2.71 × 10−9) and 6p (rs3778076, HR = 1.99, 95% CI = 1.55–2.55; P = 5.08 × 10−8), which are particularly powerful prognostic markers in patients with early stage CLL otherwise characterized by low-risk features. Expression quantitative trait loci analysis identifies putative functional genes implicated in modulating B-cell receptor or innate immune responses, key pathways in CLL pathogenesis. In this work we identify rs736456 and rs3778076 as prognostic in CLL, demonstrating that disease progression is determined by constitutional genetic variation as well as known somatic drivers.

Item Type: Article
Additional Information: ** From Springer Nature via Jisc Publications Router ** History: received 10-10-2019; accepted 16-12-2020; registration 23-12-2020; online 28-01-2021; pub-electronic 28-01-2021; collection 12-2021. ** Licence for this article: http://creativecommons.org/licenses/by/4.0/
Uncontrolled Keywords: Article, /631/67/68, /631/67/69, /631/67/1990/283/1895, /631/208/721, /692/53/2422, /45, /45/43, article
Divisions: Faculty of Health Sciences and Wellbeing > School of Nursing and Health Sciences
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SWORD Depositor: Publication Router
Depositing User: Publication Router
Date Deposited: 02 Feb 2021 11:43
Last Modified: 02 Feb 2021 11:45
URI: http://sure.sunderland.ac.uk/id/eprint/13111
ORCID for Wei-Yu Lin: ORCID iD orcid.org/0000-0002-9267-7988
ORCID for Claire Elstob: ORCID iD orcid.org/0000-0003-4252-493X
ORCID for Gordon Strathdee: ORCID iD orcid.org/0000-0001-9681-8429
ORCID for Hannah Mearns: ORCID iD orcid.org/0000-0002-8581-1288
ORCID for Timothy Barrow: ORCID iD orcid.org/0000-0003-4551-3857
ORCID for Richard S. Houlston: ORCID iD orcid.org/0000-0002-5268-0242
ORCID for Scott Marshall: ORCID iD orcid.org/0000-0001-8574-7012
ORCID for Christopher Pepper: ORCID iD orcid.org/0000-0003-3603-8839
ORCID for Francesco Forconi: ORCID iD orcid.org/0000-0002-2211-1831
ORCID for Martin J. S. Dyer: ORCID iD orcid.org/0000-0002-5033-2236
ORCID for Anna Schuh: ORCID iD orcid.org/0000-0002-3938-8490
ORCID for James Bailey: ORCID iD orcid.org/0000-0001-8540-8627
ORCID for David J. Allsup: ORCID iD orcid.org/0000-0001-6159-6109
ORCID for James M. Allan: ORCID iD orcid.org/0000-0002-7580-5087

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