The Effect of Bifidobacterium on Reducing Symptomatic Abdominal Pain in Patients with Irritable Bowel Syndrome: A Systematic Review

Pratt, Charlotte and Campbell, Matthew (2020) The Effect of Bifidobacterium on Reducing Symptomatic Abdominal Pain in Patients with Irritable Bowel Syndrome: A Systematic Review. Probiotics and Antimicrobial Proteins, 12 (3). pp. 834-839. ISSN 1867-1306

[img]
Preview
PDF
13286.pdf - Published Version
Available under License Creative Commons Attribution.

Download (433kB) | Preview

Search Google Scholar

Abstract

Probiotics, specifically Bifidobacteria, may improve abdominal pain in patients with irritable bowel syndrome (IBS); however, results from randomised controlled trials (RCTs) are conflicting. Here, we systematically reviewed the efficacy of Bifidobacteria on abdominal pain in IBS. We searched MEDLINE, EMBASE and the Cochrane Controlled Trials Register from inception to 20 May 2019, without language or date restrictions. The search strategy comprised of the combination of three concepts: supplementation, abdominal pain, and IBS. Inclusion criteria included double-blind placebo-controlled RCTs featuring Bifidobacteria supplementation in Rome-diagnosed IBS patients. A total of 8 RCTs involving a total of 1045 patients with Rome diagnosed IBS were included. The dose of total Bifidobacteria ranged from 106 to > 1011 cfu (colony-forming unit) and duration of supplementation ranged between 2 and 8 weeks. Bifidobacteria was delivered through either intake of fermented milk products, encapsulation or via a malted milk beverage, with all studies assessing abdominal pain via a visual analogue Likert scale. From the studies included, 50% (n = 4) of studies found a statistically significant improvement in abdominal pain following Bifidobacteria supplementation compared to placebo, 38% (n = 3) of studies found non-significant improvements and 12% (n = 1) showed a statistically significant dose-response effect of improvement. The evidence shows a heterogeneity of effect for Bifidobacteria dependent upon strain, dosage and delivery method. While not all studies demonstrate significant improvements in abdominal pain, none of the selected studies reported an increase in pain or other adverse effects.

Item Type: Article
Divisions: Faculty of Health Sciences and Wellbeing > School of Medicine
Depositing User: Leah Maughan
Date Deposited: 15 Mar 2021 20:41
Last Modified: 15 Apr 2021 15:06
URI: http://sure.sunderland.ac.uk/id/eprint/13286
ORCID for Matthew Campbell: ORCID iD orcid.org/0000-0001-5883-5041

Actions (login required)

View Item View Item

Downloads

Downloads per month over past year