Close menu


Sunderland Repository records the research produced by the University of Sunderland including practice-based research and theses.

Association of exercise participation levels with cardiometabolic health and quality of life in individuals with hepatitis C

Hallsworth, Kate, Gosrani, Shion, Hogg, Sarah, Patel, Preya, Wetten, Aaron, Welton, Rachael, McPherson, Stuart and Campbell, Matthew (2021) Association of exercise participation levels with cardiometabolic health and quality of life in individuals with hepatitis C. BMJ Open Gastroenterology, 8 (1). e000591. ISSN 2054-4774

Item Type: Article


Objective Hepatitis C virus (HCV) infection is associated with an increased risk of cardiovascular disease (CVD) and reduced health-related quality of life (HRQoL). Although physical activity (PA)/exercise has been shown to reduce CVD risk and improve HRQoL in patients with liver disease, there is limited data in HCV. We aimed to explore the association between PA/exercise levels, CVD risk and HRQoL in patients with HCV and assess individuals’ attitudes to PA/exercise.

Design Cross-sectional observational study recruiting consecutive patients with HCV from viral hepatitis clinics. Data were collected on CVD risk factors, anthropometry, HRQoL and the Exercise Benefits and Barriers Scale (EBBS).

Results 86 patients were recruited (71% men, 94% white, age 52±13 years); 49% of the cohort self-reported to be currently active. Although HRQoL was reduced across the cohort, patients that were regularly ‘active’ reported significantly higher HRQoL scores across Short-Form 36v2 domains compared with their inactive counterparts (p<0.05). Metabolic and cardiovascular characteristics were no different between groups stratified by PA/exercise status (p>0.05). EBBS scores were similar in the ‘active’ versus ‘inactive’ groups, however, patients categorised as ‘active’ scored significantly higher on the psychological outlook and social interaction subscales (p<0.05) than those that were ‘inactive’. There were significant associations between EBBS scores and HRQoL (p<0.05).

Conclusions PA/exercise is associated with increased HRQoL in patients with HCV irrespective of clinical parameters. Addressing specific motivators/barriers to exercise for patients will be key to designing effective PA/exercise interventions in this patient population to ensure maximum uptake and adherence.

13377.pdf - Published Version
Available under License Creative Commons Attribution Non-commercial.

Download (272kB) | Preview

More Information

Depositing User: Leah Maughan


Item ID: 13377
Identification Number:
ISSN: 2054-4774
Official URL:

Users with ORCIDS

ORCID for Matthew Campbell: ORCID iD

Catalogue record

Date Deposited: 15 Apr 2021 15:03
Last Modified: 15 Apr 2021 15:15


Author: Matthew Campbell ORCID iD
Author: Kate Hallsworth
Author: Shion Gosrani
Author: Sarah Hogg
Author: Preya Patel
Author: Aaron Wetten
Author: Rachael Welton
Author: Stuart McPherson

University Divisions

Faculty of Health Sciences and Wellbeing > School of Medicine

Actions (login required)

View Item View Item