Lyophilization-free proliposomes for sustained release oral delivery of hydrophobic drug (cinnarazine): a comparative study

Abu Abed, Omar S., Mulkala, Srilikha, Sharif, Israa, Abdin, Asma M. and Elkordy, Amal (2021) Lyophilization-free proliposomes for sustained release oral delivery of hydrophobic drug (cinnarazine): a comparative study. Pharmaceutical Technology in Hospital Pharmacy, 6 (1). ISSN 2365-242X

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Abstract

Abstract Objectives Cinnarizine is used for the treatment of vestibular disorders. However, its poor solubility limits its clinical uses due to many challenges. Liposomes were utilised to improve the release profile of many poorly soluble drugs. However, liposomes face many stability challenges during the storage period. This study aims to develop proliposomes designed for the oral delivery of cinnarizine with enhanced stability characteristics. Methods Three cinnarizine entrapping Proliposomal formulations were prepared with different ingredients and compared with their liposomal counterparts. Both vesicular approaches were characterised for their particle size, encapsulation efficiency, drug release and stability. Results The proliposomes were superior to liposomes in their stability and release profiles. Although no significant changes were noticed between the encapsulation efficiency percentage of the liposomal and proliposomal formulations on the day of preparation, storing the formulations for two weeks ended up with significant leakage of the drug from liposomes (p < 0.05) due to stability issues, but not in proliposomes. Moreover, the proliposomes released 100% of cinnarizine throughout the dissolution experiment in gastric fluid in comparison with the total released drug of 70% from the liposomes. Conclusions Proliposomes provided a successful approach to deliver lipophilic drugs orally to improve their pharmacokinetic properties by converting their crystalline nature into more amorphous agents.

Item Type: Article
Divisions: Faculty of Health Sciences and Wellbeing > School of Pharmacy and Pharmaceutical Sciences
SWORD Depositor: Publication Router
Depositing User: Publication Router
Date Deposited: 05 Jul 2021 08:45
Last Modified: 05 Jul 2021 08:45
URI: http://sure.sunderland.ac.uk/id/eprint/13572
ORCID for Omar S. Abu Abed: ORCID iD orcid.org/0000-0002-7118-2441
ORCID for Israa Sharif: ORCID iD orcid.org/0000-0002-1195-2221
ORCID for Amal Elkordy: ORCID iD orcid.org/0000-0002-0781-1127

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