Close menu


Sunderland Repository records the research produced by the University of Sunderland including practice-based research and theses.

Lyophilization-free proliposomes for sustained release oral delivery of hydrophobic drug (cinnarazine): a comparative study

Abu Abed, Omar S., Mulkala, Srilikha, Sharif, Israa, Abdin, Asma M. and Elkordy, Amal (2021) Lyophilization-free proliposomes for sustained release oral delivery of hydrophobic drug (cinnarazine): a comparative study. Pharmaceutical Technology in Hospital Pharmacy, 6 (1). ISSN 2365-242X

Item Type: Article


Abstract Objectives Cinnarizine is used for the treatment of vestibular disorders. However, its poor solubility limits its clinical uses due to many challenges. Liposomes were utilised to improve the release profile of many poorly soluble drugs. However, liposomes face many stability challenges during the storage period. This study aims to develop proliposomes designed for the oral delivery of cinnarizine with enhanced stability characteristics. Methods Three cinnarizine entrapping Proliposomal formulations were prepared with different ingredients and compared with their liposomal counterparts. Both vesicular approaches were characterised for their particle size, encapsulation efficiency, drug release and stability. Results The proliposomes were superior to liposomes in their stability and release profiles. Although no significant changes were noticed between the encapsulation efficiency percentage of the liposomal and proliposomal formulations on the day of preparation, storing the formulations for two weeks ended up with significant leakage of the drug from liposomes (p < 0.05) due to stability issues, but not in proliposomes. Moreover, the proliposomes released 100% of cinnarizine throughout the dissolution experiment in gastric fluid in comparison with the total released drug of 70% from the liposomes. Conclusions Proliposomes provided a successful approach to deliver lipophilic drugs orally to improve their pharmacokinetic properties by converting their crystalline nature into more amorphous agents.

13572.pdf - Published Version
Available under License Creative Commons Attribution.

Download (334kB) | Preview

More Information

SWORD Depositor: Publication Router
Depositing User: Publication Router


Item ID: 13572
Identification Number:
ISSN: 2365-242X
Official URL:

Users with ORCIDS

ORCID for Omar S. Abu Abed: ORCID iD
ORCID for Israa Sharif: ORCID iD
ORCID for Amal Elkordy: ORCID iD

Catalogue record

Date Deposited: 05 Jul 2021 08:45
Last Modified: 05 Jul 2021 08:45


Author: Omar S. Abu Abed ORCID iD
Author: Israa Sharif ORCID iD
Author: Amal Elkordy ORCID iD
Author: Srilikha Mulkala
Author: Asma M. Abdin

University Divisions

Faculty of Health Sciences and Wellbeing > School of Pharmacy and Pharmaceutical Sciences

Actions (login required)

View Item View Item