Close menu


Sunderland Repository records the research produced by the University of Sunderland including practice-based research and theses.

Postprandial vascular-inflammatory and thrombotic responses to high-fat feeding are augmented by manipulating the lipid droplet size distribution

Howard, Emma, Attenbourgh, Abigail, O'Mahoney, Lauren L., Sakar, Anwesha, Ke, Lijin and Campbell, Matthew (2021) Postprandial vascular-inflammatory and thrombotic responses to high-fat feeding are augmented by manipulating the lipid droplet size distribution. Nutrition, Metabolism and Cardiovascular Diseases. ISSN 0939-4753

Item Type: Article


Background and Aims
Postprandial responses are influenced not only by the type and amount of fat ingested, but also lipid droplet size distribution. However, little research has investigated the impact of differential lipid size distributions within a mixed-macronutrient meal context on postprandial vascular health. Therefore, we examined whether manipulating the lipid droplet size distribution within a mixed-macronutrient meal impacts vascular-inflammatory and thrombotic parameters.
Methods and Results
In a randomised and counterbalanced fashion, sixteen adults (8 males; age 34±7 years; BMI of 25.3±4.5 kg/m2) completed three separate fasted morning-time feeding challenges, each separated by a minimum washout of 7-days. On each occasion, test-meals matched for carbohydrate and protein content differing only in fat amount and the lipid droplet size distribution were administered, such that participants consumed (1) a low-fat meal (LF) with negligible fat content, (2) an emulsified-high-fat meal with a fine lipid droplet size (FE), or (3) an emulsified-high-fat meal with a coarse lipid droplet size (CE). Periodic blood samples were retrospectively analysed for plasma triglycerides, tumour necrosis factor alpha (TNFα), tissue factor (TF), fibrinogen, and plasminogen activator inhibitor-1 (PAI-1). Triglyceride concentrations increased rapidly overtime under FE (P-time<0.05); this rise was attenuated under CE (P-time>0.05) and was comparable to LF (P-condition>0.05). Similarly, FE induced a significant rise in TNFα, TF, fibrinogen, and PAI-1 (P-time<0.05); these parameters remained unchanged under LF and CE (P-time>0.05).
A high-fat mixed-macronutrient meal with a larger lipid droplet size distribution ameliorates the associated rise in vascular-inflammatory and thrombotic parameters.

13639.pdf - Accepted Version
Available under License Creative Commons Attribution Non-commercial No Derivatives.

Download (861kB) | Preview

More Information

Depositing User: Leah Maughan


Item ID: 13639
Identification Number:
ISSN: 0939-4753
Official URL:

Users with ORCIDS

ORCID for Matthew Campbell: ORCID iD

Catalogue record

Date Deposited: 25 Jun 2021 14:25
Last Modified: 03 Jun 2022 02:38


Author: Matthew Campbell ORCID iD
Author: Emma Howard
Author: Abigail Attenbourgh
Author: Lauren L. O'Mahoney
Author: Anwesha Sakar
Author: Lijin Ke

University Divisions

Faculty of Health Sciences and Wellbeing > School of Nursing and Health Sciences

Actions (login required)

View Item View Item