Close menu


Sunderland Repository records the research produced by the University of Sunderland including practice-based research and theses.

Interrupted sitting improves 24-hour glucose control in people with type 1 diabetes [Conference abstract]

Campbell, Matthew, Dingena, C, Marsh, A, Coales, EM, O'Mahoney, Lauren L., Dempsey, P, Francois, M, Ajjan, R and Alobaid, A (2020) Interrupted sitting improves 24-hour glucose control in people with type 1 diabetes [Conference abstract]. Diabetologia 63, 56th EASD Annual Meeting of the European Association for the Study of Diabetes.

Item Type: Other


Background and aims: Interrupting prolonged periods of sitting with short, frequent light-intensity walking improves 24-hour glucose control Diabetologia in people with and at risk of Type 2 Diabetes. However, it is unknown whether and how such an intervention influences 24-hour glucose control, including risk of hypoglycaemia, in people with Type 1 Diabetes (T1D). Therefore, we evaluated the effect of short, frequent bouts of light-intensity walking on 24-hour glycaemia in people with T1D. Materials and methods: In a randomised crossover design, ten inactive adults with T1D (6 men; mean±SD: 30±34.7 years) completed two morning (~08:00am) laboratory visits in a fasted state, each separated by at least 1-week. On both visits, participants consumed a standardised carbohydrate-based meal with their usual insulin dose determined by the carbohydrate-counting method; the meal and insulin dose were identical on each visit. After consuming the meal, participants underwent two experimental conditions: (1) uninterrupted sitting (SIT); or (2) sitting interrupted with 5-minute bouts of light-intensity walking every 30- minutes for 4-hours (SIT-Less). Interstitial glucose responses were measured using continuous glucose monitoring (CGM) during the 4- hour laboratory visit for a further 20-hours under free-living conditions. Results: Compare to SIT, whole-day glycaemia was significantly lower following SIT-Less; 24-hour interstitial glucose Area Under the Curve was -14%[1.2%] under SIT-Less (p=0.023), accompanied by a significantly smaller average change in interstitial glucose from baseline (SIT: Δ1.5±2.5 vs. SIT-Less Δ-0.01±1.6 mmol/L, p=0.001), and lower average interstitial glucose peak (SIT:Δ7.7±3.0 vs. SIT-Less Δ3.9±1.4 mmol/L, p=0.002). Furthermore, with SIT-Less, Time in Range (TIR; 3.9-10 mmol/L), was significantly greater (TIR: SIT 991.5±286.86 vs. SIT-Less 1240.5±173.5 minutes, p=0.030), while time spent in hyperglycaemia was significantly lower (SIT 413.5±266.8 vs. SIT-Less 162±163.6 minutes, p=0.020). However, time spent in hypoglycaemia was similar between conditions (SIT 35±68.68 vs. SIT-Less 37.5±62.19 minutes, p=0.933). Glycaemic variability was lower with SIT-Less (CV%: SIT 29.4±7.6 vs. SIT-Less 22.1±7.5 %, p=0.021). Conclusion: Interrupting sitting time, with brief light-intensity walking activity, significantly improves whole-day glucose control in people with T1D. These preliminary findings suggest that interrupted sitting may serve as an effective and practical means of normalising daily glucose levels in people with T1D by increasing time in range and reducing glycaemic variability, without increasing the risk of hypoglycaemia.

Full text not available from this repository.

More Information

Depositing User: Leah Maughan


Item ID: 13820
Identification Number: 399
Official URL:

Users with ORCIDS

ORCID for Matthew Campbell: ORCID iD

Catalogue record

Date Deposited: 10 Aug 2021 09:51
Last Modified: 10 Aug 2021 09:51


Author: Matthew Campbell ORCID iD
Author: C Dingena
Author: A Marsh
Author: EM Coales
Author: Lauren L. O'Mahoney
Author: P Dempsey
Author: M Francois
Author: R Ajjan
Author: A Alobaid

University Divisions

Faculty of Health Sciences and Wellbeing > School of Nursing and Health Sciences

Actions (login required)

View Item View Item