Close menu


Sunderland Repository records the research produced by the University of Sunderland including practice-based research and theses.

Brief on Recent Application of Liposomal Vaccines for Lower Respiratory Tract Viral Infections: From Influenza to COVID-19 Vaccines

Attia, Mohamed Ahmed, Essa, Ebtessam Ahmed, Elebyary, Toka Tarek, Faheem, Ahmed Mostafa and Elkordy, Amal (2021) Brief on Recent Application of Liposomal Vaccines for Lower Respiratory Tract Viral Infections: From Influenza to COVID-19 Vaccines. Pharmaceuticals, 14 (11). e1173. ISSN 1424-8247

Item Type: Article


Vaccination is the most effective means of preventing infectious diseases and saving lives. Modern biotechnology largely enabled vaccine development. In the meantime, recent advances in pharmaceutical technology have resulted in the emergence of nanoparticles that are extensively investigated as promising miniaturized drug delivery systems. Scientists are particularly interested in liposomes as an important carrier for vaccine development. Wide acceptability of liposomes lies in their flexibility and versatility. Due to their unique vesicular structure with alternating aqueous and lipid compartments, liposomes can enclose both hydrophilic and lipophilic compounds, including antigens. Liposome composition can be tailored to obtain the desired immune response and adjuvant characteristics. During the current pandemic of COVID-19, many liposome-based vaccines have been developed with great success. This review covers a liposome-based vaccine designed particularly to combat viral infection of the lower respiratory tract (LRT), i.e., infection of the lung, specifically in the lower airways. Viruses such as influenza, respiratory syncytial virus (RSV), severe acute respiratory syndrome (SARS-CoV-1 and SARS-CoV-2) are common causes of LRT infections, hence this review mainly focuses on this category of viruses.

pharmaceuticals-14-01173.pdf - Published Version
Available under License Creative Commons Attribution.

Download (1MB) | Preview

More Information

Additional Information: ** From MDPI via Jisc Publications Router ** History: accepted 14-11-2021; pub-electronic 17-11-2021. ** Licence for this article:
Uncontrolled Keywords: nanoparticles, SARS-CoV, adjuvants, liposomes, vaccines
Related URLs:
SWORD Depositor: Publication Router
Depositing User: Publication Router


Item ID: 14198
Identification Number:
ISSN: 1424-8247
Official URL:

Users with ORCIDS

ORCID for Mohamed Ahmed Attia: ORCID iD
ORCID for Amal Elkordy: ORCID iD

Catalogue record

Date Deposited: 10 Dec 2021 09:37
Last Modified: 29 Mar 2022 14:47


Author: Mohamed Ahmed Attia ORCID iD
Author: Amal Elkordy ORCID iD
Author: Ebtessam Ahmed Essa
Author: Toka Tarek Elebyary
Author: Ahmed Mostafa Faheem

University Divisions

Faculty of Health Sciences and Wellbeing > School of Nursing and Health Sciences

Actions (login required)

View Item View Item