Brief on Recent Application of Liposomal Vaccines for Lower Respiratory Tract Viral Infections: From Influenza to COVID-19 Vaccines

Attia, Mohamed Ahmed, Essa, Ebtessam Ahmed, Elebyary, Toka Tarek, Faheem, Ahmed Mostafa and Elkordy, Amal Ali (2021) Brief on Recent Application of Liposomal Vaccines for Lower Respiratory Tract Viral Infections: From Influenza to COVID-19 Vaccines. Pharmaceuticals, 14 (11). e1173. ISSN 1424-8247

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Abstract

Vaccination is the most effective means of preventing infectious diseases and saving lives. Modern biotechnology largely enabled vaccine development. In the meantime, recent advances in pharmaceutical technology have resulted in the emergence of nanoparticles that are extensively investigated as promising miniaturized drug delivery systems. Scientists are particularly interested in liposomes as an important carrier for vaccine development. Wide acceptability of liposomes lies in their flexibility and versatility. Due to their unique vesicular structure with alternating aqueous and lipid compartments, liposomes can enclose both hydrophilic and lipophilic compounds, including antigens. Liposome composition can be tailored to obtain the desired immune response and adjuvant characteristics. During the current pandemic of COVID-19, many liposome-based vaccines have been developed with great success. This review covers a liposome-based vaccine designed particularly to combat viral infection of the lower respiratory tract (LRT), i.e., infection of the lung, specifically in the lower airways. Viruses such as influenza, respiratory syncytial virus (RSV), severe acute respiratory syndrome (SARS-CoV-1 and SARS-CoV-2) are common causes of LRT infections, hence this review mainly focuses on this category of viruses.

Item Type: Article
Additional Information: ** From MDPI via Jisc Publications Router ** History: accepted 14-11-2021; pub-electronic 17-11-2021. ** Licence for this article: https://creativecommons.org/licenses/by/4.0/
Uncontrolled Keywords: nanoparticles, SARS-CoV, adjuvants, liposomes, vaccines
Divisions: Faculty of Health Sciences and Wellbeing > School of Nursing and Health Sciences
Related URLs:
SWORD Depositor: Publication Router
Depositing User: Publication Router
Date Deposited: 10 Dec 2021 09:37
Last Modified: 10 Dec 2021 09:37
URI: http://sure.sunderland.ac.uk/id/eprint/14198
ORCID for Mohamed Ahmed Attia: ORCID iD orcid.org/0000-0002-2886-4789
ORCID for Amal Ali Elkordy: ORCID iD orcid.org/0000-0002-0781-1127

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