Characterization of Individualized Glycemic Excursions during a Standardized Bout of Hypoglycemia-Inducing Exercise and Subsequent Hypoglycemia Treatment—A Pilot Study

Brož, Jan, Campbell, Matthew D., Urbanová, Jana, Nunes, Marisa A., Brunerová, Ludmila, Rahelić, Dario, Janíčková Žďárská, Denisa, Taniwall, Arian, Brabec, Marek, Berka, Vojtěch, Michalec, Juraj and Polák, Jan (2021) Characterization of Individualized Glycemic Excursions during a Standardized Bout of Hypoglycemia-Inducing Exercise and Subsequent Hypoglycemia Treatment—A Pilot Study. Nutrients, 13 (11). e4165. ISSN 2072-6643

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Abstract

The glycemic response to ingested glucose for the treatment of hypoglycemia following exercise in type 1 diabetes patients has never been studied. Therefore, we aimed to characterize glucose dynamics during a standardized bout of hypoglycemia-inducing exercise and the subsequent hypoglycemia treatment with the oral ingestion of glucose. Ten male patients with type 1 diabetes performed a standardized bout of cycling exercise using an electrically braked ergometer at a target heart rate (THR) of 50% of the individual heart rate reserve, determined using the Karvonen equation. Exercise was terminated when hypoglycemia was reached, followed by immediate hypoglycemia treatment with the oral ingestion of 20 g of glucose. Arterialized blood glucose (ABG) levels were monitored at 5 min intervals during exercise and for 60 min during recovery. During exercise, ABG decreased at a mean rate of 0.11 ± 0.03 mmol/L·min−1 (minimum: 0.07, maximum: 0.17 mmol/L·min−1). During recovery, ABG increased at a mean rate of 0.13 ± 0.05 mmol/L·min−1 (minimum: 0.06, maximum: 0.19 mmol/L·min−1). Moreover, 20 g of glucose maintained recovery from hypoglycemia throughout the 60 min postexercise observation window.

Item Type: Article
Additional Information: ** From MDPI via Jisc Publications Router ** History: accepted 18-11-2021; pub-electronic 21-11-2021. ** Licence for this article: https://creativecommons.org/licenses/by/4.0/
Uncontrolled Keywords: type 1 diabetes, exercise, hypoglycemia, insulin therapy, glycemic excursion, hypoglycemia treatment
Divisions: Faculty of Health Sciences and Wellbeing > School of Nursing and Health Sciences
Related URLs:
SWORD Depositor: Publication Router
Depositing User: Publication Router
Date Deposited: 09 Dec 2021 16:59
Last Modified: 09 Dec 2021 16:59
URI: http://sure.sunderland.ac.uk/id/eprint/14206
ORCID for Jan Brož: ORCID iD orcid.org/0000-0003-2465-7333
ORCID for Matthew D. Campbell: ORCID iD orcid.org/0000-0001-5883-5041
ORCID for Marisa A. Nunes: ORCID iD orcid.org/0000-0002-1864-6964
ORCID for Dario Rahelić: ORCID iD orcid.org/0000-0002-2901-0646
ORCID for Arian Taniwall: ORCID iD orcid.org/0000-0001-7174-4451

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