Oxygen levels are key to understanding “Anaerobic” protozoan pathogens with micro-aerophilic lifestyles

Lloyd, David, Chapman, Alan, Ellis, Jayne E., Hillman, Kevin, Paget, Timothy, Yarlett, Nigel and Williams, Alan G. (2021) Oxygen levels are key to understanding “Anaerobic” protozoan pathogens with micro-aerophilic lifestyles. Advances in Microbial Physiology, 79. pp. 163-240. ISSN 0065-2911

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Abstract

Publications abound on the physiology, biochemistry and molecular biology of “anaerobic” protozoal parasites as usually grown under “anaerobic” culture conditions. The media routinely used are poised at low redox potentials using techniques that remove O2 to “undetectable” levels in sealed containers. However there is growing understanding that these culture conditions do not faithfully resemble the O2 environments these organisms inhabit. Here we review for protists lacking oxidative energy metabolism, the oxygen cascade from atmospheric to intracellular concentrations and relevant methods of measurements of O2, some well-studied parasitic or symbiotic protozoan lifestyles, their homeodynamic metabolic and redox balances, organism-drug-oxygen interactions, and the present and future prospects for improved drugs and treatment regimes.

Item Type: Article
Additional Information: Book Series. ISBN: 9780128246023
Divisions: Faculty of Health Sciences and Wellbeing > School of Medicine
Depositing User: Leah Maughan
Date Deposited: 24 Nov 2021 14:07
Last Modified: 03 Dec 2021 15:50
URI: http://sure.sunderland.ac.uk/id/eprint/14212
ORCID for Timothy Paget: ORCID iD orcid.org/0000-0002-9758-8044

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