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Prior COVID-19 infection is associated with increased Adverse Events (AEs) after the first, but not the second, dose of the BNT162b2/Pfizer vaccine

Raw, Rachael K., Rees, Jon, Kelly, Clive A., Wroe, Caroline and Chadwick, David R. (2021) Prior COVID-19 infection is associated with increased Adverse Events (AEs) after the first, but not the second, dose of the BNT162b2/Pfizer vaccine. Vaccine. ISSN 0264-410X

Item Type: Article

Abstract

The BNT162b2/Pfizer SARS-CoV-2 vaccine has been widely used in the UK, particularly amongst healthcare workers (HCWs). To establish whether previous COVID-19 influenced vaccine-associated Adverse Events (AEs), we conducted a survey-based study of HCWs in Northeast England. Out of 1238 HCWs, 32% self-reported prior positive PCR and/or antibody test for SARS-CoV-2. Post-dose AEs were worse in those with prior COVID-19 after the first, but not the second dose of vaccine. Second dose AEs were greater in frequency/severity, regardless of COVID-19 history, and they were more systemic in nature. Women and younger HCW were more likely to report AEs after both doses, while dosing interval had no effect on AEs. Ongoing Symptomatic COVID-19 was associated with greater frequency/severity of AEs after dose 2, but not dose one. Overall, AEs were self-limiting and short-lived (i.e.,<48 h) in nature. These findings have implications for vaccine hesitancy and informing guidelines for recommended dosing protocols.

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More Information

Depositing User: Leah Maughan

Identifiers

Item ID: 14265
Identification Number: https://doi.org/10.1016/j.vaccine.2021.11.090
ISSN: 0264-410X
URI: http://sure.sunderland.ac.uk/id/eprint/14265
Official URL: http://dx.doi.org/10.1016/j.vaccine.2021.11.090

Users with ORCIDS

ORCID for Jon Rees: ORCID iD orcid.org/0000-0002-3295-244X

Catalogue record

Date Deposited: 11 Jan 2022 11:39
Last Modified: 11 Jan 2022 11:39

Contributors

Author: Jon Rees ORCID iD
Author: Rachael K. Raw
Author: Clive A. Kelly
Author: Caroline Wroe
Author: David R. Chadwick

University Divisions

Faculty of Health Sciences and Wellbeing > School of Nursing and Health Sciences

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