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Sunderland Repository records the research produced by the University of Sunderland including practice-based research and theses.

Regulation of glycogen synthesis in human muscle cells

Yeaman, SJ, Armstrong, Jane, Bonavaud, SM, Poinasamy, D, Pickersgill, L and Halse, R (2001) Regulation of glycogen synthesis in human muscle cells. Biochemical Society Transactions.

Item Type: Article


Glucose uptake into muscle and its subsequent storage as glycogen is a crucial factor in energy homeostasis in skeletal muscle. This process is stimulated acutely by insulin and is impaired in both insulin-resistant states and in type 2 diabetes mellitus. A signalling pathway involving protein kinase B and glycogen synthase kinase 3 seems certain to have a key role in stimulating glycogen synthesis but other signalling pathways also contribute, including a rapamycin-sensitive pathway stimulated by amino acids. Although glycogen synthesis is one of the classical insulin-regulated pathways, it is also regulated in an insulin-independent manner; for example glycogen synthesis in muscle is stimulated significantly after strenuous exercise, with much of this stimulation being independent of the involvement of insulin. Evidence suggests that glucose and the glycogen content of the muscle have a key role in this stimulation but the molecular mechanism has yet to be fully explained.

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More Information

Depositing User: Jane Armstrong


Item ID: 14495
Identification Number:
Official URL:

Users with ORCIDS

ORCID for Jane Armstrong: ORCID iD

Catalogue record

Date Deposited: 04 Feb 2022 16:16
Last Modified: 04 Feb 2022 16:16


Author: Jane Armstrong ORCID iD
Author: SJ Yeaman
Author: SM Bonavaud
Author: D Poinasamy
Author: L Pickersgill
Author: R Halse

University Divisions

Faculty of Health Sciences and Wellbeing > School of Nursing and Health Sciences


Sciences > Biomedical Sciences

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