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Parental childhood vaccine hesitancy and predicting uptake of vaccinations: a systematic review

Obohwemu, Kennedy, Christie-de Jong, Floor and Ling, Jonathan (2022) Parental childhood vaccine hesitancy and predicting uptake of vaccinations: a systematic review. Primary Health Care Research and Development, 23. pp. 1-14. ISSN 1463-4236

Item Type: Article


Aim: This review aims are to (1) identify relevant quantitative research on parental childhood vaccine hesitancy with vaccine uptake and vaccination intention being relevant outcomes and
(2) map the gaps in knowledge on vaccine hesitancy to develop suggestions for further research and to guide interventions in this field. Background: Vaccine hesitancy recognises a continuum
between vaccine acceptance and vaccine refusal, de-polarising past anti-vaccine, and provaccine categorisations of individuals and groups. Vaccine hesitancy poses a serious challenge to international efforts to lessen the burden of vaccine-preventable diseases. Potential vaccina�tion barriers must be identified to inform initiatives aimed at increasing vaccine awareness, acceptance, and uptake. Methods: Five databases were searched for peer-reviewed articles published between 1998 and 2020 in the fields of medicine, nursing, public health, biological sciences, and social sciences. Across these datasets, a comprehensive search technique was used
to identify multiple variables of public trust, confidence, and hesitancy about vaccines. Using PRISMA guidelines, 34 papers were included so long as they focused on childhood immunisa�tions, employed multivariate analysis, and were published during the time frame. Significant challenges to vaccine uptake or intention were identified in these studies. Barriers to vaccination for the target populations were grouped using conceptual frameworks based on the Protection Motivation Theory and the World Health Organization’s Strategic Advisory Group of Experts on Immunization Working Group model and explored using the 5C psychological antecedents of vaccination. Findings: Although several characteristics were shown to relate to vaccine hesitancy, they do not allow for a thorough classification or proof of their individual and comparative level of influence. Understudied themes were also discovered during the review. Lack of confidence, complacency, constraints, calculation and collective responsibility have all been
highlighted as barriers to vaccination uptake among parents to different degrees.

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Uncontrolled Keywords: childhood vaccines, confidence, immunisation, hesitancy, parents, public trust, vaccination, vaccine
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Depositing User: Jonathan Ling


Item ID: 15634
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ISSN: 1463-4236
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ORCID for Floor Christie-de Jong: ORCID iD
ORCID for Jonathan Ling: ORCID iD

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Date Deposited: 20 Feb 2023 09:56
Last Modified: 20 Feb 2023 09:56


Author: Floor Christie-de Jong ORCID iD
Author: Jonathan Ling ORCID iD
Author: Kennedy Obohwemu

University Divisions

Faculty of Health Sciences and Wellbeing


Sciences > Health Sciences

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