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Sunderland Repository records the research produced by the University of Sunderland including practice-based research and theses.

Novel Crosslinked HA Hydrogel Films for the Immediate Release of Active Ingredients

Dodou, Kalliopi and Rashid, Fatimah (2022) Novel Crosslinked HA Hydrogel Films for the Immediate Release of Active Ingredients. Cosmetics, 10 (16). pp. 1-18. ISSN 2079-9284

Item Type: Article


Novel crosslinked hyaluronic acid (HA) hydrogel films were previously invented by reacting the HA polymer with the PT (Pentaerythritol Tetra-acrylate) crosslinker over basic pH conditions in the oven. HA is considered a natural polymer present in cosmetic as well as pharmaceutical formulations. This current study aimed to highlight the effect of loading method (post-loading and in situ) of selected actives (salicylic acid and niacinamide B3) in the hydrogel films and then study their release kinetics. Differential scanning colometry (DSC) and Fourier transform infrared spectroscopy (FTIR) analysis evidenced the loading of the actives and full release from the HA hydrogel films, while the scanning electron microscopy (SEM) demonstrated the morphological changes to the films during the study by comparing the average molecular weight between crosslinks (M¯¯¯¯c), gel fraction, crosslinking density (Ve) and mesh size (ξ) of the films. The loading percentage of the SA and B3 showed high percentage loading of actives via both loading methods. In conclusion, the (95–100%) release of the actives achieved from the HA hydrogel films within 10 min revealed that the films are an efficient immediate release system of actives.

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cosmetics-10-00006-v3.pdf - Published Version
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Uncontrolled Keywords: hyaluronic acid; pentaerythritol tetra acrylate; hydrogels; cosmetics; niacinamide B3; salicylic acid; DSC; FTIR; SEM
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Depositing User: Kalli Dodou


Item ID: 15643
Identification Number:
ISSN: 2079-9284
Official URL:

Users with ORCIDS

ORCID for Kalliopi Dodou: ORCID iD

Catalogue record

Date Deposited: 20 Feb 2023 11:46
Last Modified: 20 Feb 2023 11:46


Author: Kalliopi Dodou ORCID iD
Author: Fatimah Rashid

University Divisions

Faculty of Health Sciences and Wellbeing


Sciences > Chemistry
Sciences > Pharmacy and Pharmacology

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