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Traumatic Brain Injuries: Pathophysiology and potential therapeutic targets

LEE, Alan YW (2019) Traumatic Brain Injuries: Pathophysiology and potential therapeutic targets. Frontiers in Cellular Neuroscience, 13. p. 528. ISSN 1662-5102

Item Type: Article


Traumatic brain injury (TBI) remains one of the leading causes of morbidity and mortality amongst civilians and military personnel globally. Despite advances in our knowledge
of the complex pathophysiology of TBI, the underlying mechanisms are yet to be fully elucidated. While initial brain insult involves acute and irreversible primary damage to the
parenchyma, the ensuing secondary brain injuries often progress slowly over months to years, hence providing a window for therapeutic interventions. To date, hallmark
events during delayed secondary CNS damage include Wallerian degeneration of axons, mitochondrial dysfunction, excitotoxicity, oxidative stress and apoptotic cell death of
neurons and glia. Extensive research has been directed to the identification of druggable targets associated with these processes. Furthermore, tremendous effort has been put forth to improve the bioavailability of therapeutics to CNS by devising strategies for efficient, specific and controlled delivery of bioactive agents to cellular targets. Here, we give an overview of the pathophysiology of TBI and the underlying molecular mechanisms, followed by an update on novel therapeutic targets and agents. Recent development of various approaches of drug delivery to the CNS is also discussed.

Traumatic Brain Injuries-Pathophysiology and Potential Therapeutic Targets - Front Cell Neurosci 2019.pdf - Accepted Version
Available under License Creative Commons Attribution Non-commercial No Derivatives.

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Uncontrolled Keywords: CNS trauma, secondary injuries, neuronal regeneration, cell penetrating proteins, biopolymers, controlled drug release
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Depositing User: Alan Lee


Item ID: 16003
Identification Number:
ISSN: 1662-5102
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Catalogue record

Date Deposited: 05 May 2023 15:53
Last Modified: 11 Jul 2023 08:02


Author: Alan YW LEE ORCID iD

University Divisions

Faculty of Health Sciences and Wellbeing > School of Pharmacy and Pharmaceutical Sciences


Sciences > Biomedical Sciences
Sciences > Pharmacy and Pharmacology

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