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Exploration of the tumor suppressor function of semaphorin 5A in brain cancer treatment

LEE, Alan YW (2021) Exploration of the tumor suppressor function of semaphorin 5A in brain cancer treatment. Frontiers in Pharmacology. p. 44. ISSN 1663-9812

Item Type: Article


Astrocytomas are the most common forms of brain tumor in human, among which glioblastoma mutliforme is highly malignant and exhibits high invasiveness and resistance to chemo- and radiotherapy, leading to high recurrence rate even after radical surgical resection of the tumor and a median survival of only 15 months after initial diagnosis. This calls for the development of novel effective treatment regimens, which apparently requires a more thorough
understanding of the pathoetiology of glioblastomas at both cellular and molecular levels. Recently, accumulating evidence points to the emerging role of axon guidance molecules such as semaphorins, neuropilins and plexins in glioma progression. We have demonstrated the effects of semaphorin
5A (Sema5A) and its receptor plexin-B3 in inhibiting glioma cell migration, invasion and proliferation. Notably, analysis of clinical specimens revealed a marked decline in Sema5A protein level in high-grade human glioblastomas, suggesting a correlation between its loss of function and tumor progression. Restoration of Sema5A level by forced expression or exogenous supply of Sema5A protein successfully counteracts tumorigenicity of glioblastoma cells. These findings provide compelling evidence that Sema5A and plexin-B3 subserve anti-tumorigenic functions, which are compromised in glioblastomas due to a downregulation of Sema5A protein expression, hence contributing to high infiltration and malignancy. In this presentation, the mechanisms of tumor suppressor effect of Sema5A and the exploration of its therapeutic potential will be discussed.

MSPP 34th Scientific Meeting 2021 - ISBN 9782889710089.PDF - Published Version

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Uncontrolled Keywords: Astrocytomas, Semaphorin 5A, Receptor plexin-B3, Tumor suppresor
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Depositing User: Alan Lee


Item ID: 16007
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ISSN: 1663-9812

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Date Deposited: 11 May 2023 14:51
Last Modified: 11 Jul 2023 08:02