Close menu


Sunderland Repository records the research produced by the University of Sunderland including practice-based research and theses.

Vascular biology: the role of sphingosine 1-phosphate in both the resting state and inflammation.

Swan, David, Kirby, John A and Ali, Simi (2010) Vascular biology: the role of sphingosine 1-phosphate in both the resting state and inflammation. Journal of cellular and molecular medicine, 14 (9). pp. 2211-22. ISSN 1582-4934

Item Type: Article


The vascular and immune systems of mammals are closely intertwined: the individual components of the immune system must move between various body compartments to perform their function effectively. Sphingosine 1-phosphate (S1P), a bioactive lipid mediator, exerts effects on the two organ systems and influences the interaction between them. In the resting state, the vascular S1P gradient contributes to control of lymphocyte recirculation through the blood, lymphoid tissue and lymphatic vasculature. The high level of S1P in blood helps maintain endothelial barrier integrity. During the inflammatory process, both the level of S1P in different immune compartments and S1P receptor expression on lymphocytes and endothelial cells are modified, resulting in functionally important changes in endothelial cell and lymphocyte behaviour. These include transient arrest of lymphocytes in secondary lymphoid tissue, crucial for generation of adaptive immunity, and subsequent promotion of lymphocyte recruitment to sites of inflammation. This review begins with an outline of the basic biochemistry of S1P. S1P receptor signalling is then discussed, followed by an exploration of the roles of S1P in the vascular and immune systems, with particular focus on the interface between them. The latter part concerns crosstalk between S1P and other signalling pathways, and concludes with a look at therapies targeting the S1P-S1P receptor axis.

Full text not available from this repository.

More Information

Uncontrolled Keywords: sphingosine 1-phosphate, inflammation, endothelial cell, lymphocyte
Depositing User: David Swan


Item ID: 16667
Identification Number:
ISSN: 1582-4934
Official URL:

Users with ORCIDS

ORCID for David Swan: ORCID iD

Catalogue record

Date Deposited: 05 Oct 2023 09:15
Last Modified: 09 Oct 2023 09:44


Author: David Swan ORCID iD
Author: John A Kirby
Author: Simi Ali

University Divisions

Faculty of Health Sciences and Wellbeing > School of Medicine


Sciences > Biomedical Sciences

Actions (login required)

View Item View Item