Close menu


Sunderland Repository records the research produced by the University of Sunderland including practice-based research and theses.

ST3 beta-galactoside alpha-2,3-sialyltransferase 1 (ST3Gal1) synthesis of Siglec ligands mediates anti-tumour immunity in prostate cancer

Garnham, Rebecca, Geh, Daniel, Nelson, Ryan, Ramon-Gil, Erik, Wilson, Laura, Schmidt, Edward N, Walker, Laura, Adamson, Beth, Buskin, Adriana, Hepburn, Anastasia C, Hodgson, Kirsty, Kendall, Hannah, Frame, Fiona M, Maitland, Norman, Coffey, Kelly, Strand, Douglas W, Robson, Craig N, Elliott, David J, Heer, Rakesh, Macauley, Matthew, Munkley, Jennifer, Gaughan, Luke, Leslie, Jack and Scott, Emma (2024) ST3 beta-galactoside alpha-2,3-sialyltransferase 1 (ST3Gal1) synthesis of Siglec ligands mediates anti-tumour immunity in prostate cancer. Communications Biology, 7. ISSN 2399-3642

Item Type: Article


Immune checkpoint blockade has yet to produce robust anti-cancer responses for prostate cancer. Sialyltransferases have been shown across several solid tumours, including breast, melanoma, colorectal and prostate to promote immune suppression by synthesising sialoglycans, which act as ligands for Siglec receptors. We report that ST3 beta-galactoside alpha-2,3-sialyltransferase 1 (ST3Gal1) levels negatively correlate with androgen signalling in prostate tumours. We demonstrate that ST3Gal1 plays an important role in modulating tumour immune evasion through the synthesises of sialoglycans with the capacity to engage the Siglec-7 and Siglec-9 immunoreceptors preventing immune clearance of cancer cells. Here, we provide evidence of the expression of Siglec-7/9 ligands and their respective immunoreceptors in prostate tumours. These interactions can be modulated by enzalutamide and may maintain immune suppression in enzalutamide treated tumours. We conclude that the activity of ST3Gal1 is critical to prostate cancer anti-tumour immunity and provide rationale for the use of glyco-immune checkpoint targeting therapies in advanced prostate cancer.

Available under License Creative Commons Attribution.

Download (3MB) | Preview

More Information

Related URLs:
Depositing User: Rebecca Garnham


Item ID: 17652
Identification Number:
ISSN: 2399-3642
Official URL:

Users with ORCIDS

Catalogue record

Date Deposited: 21 Jun 2024 13:27
Last Modified: 21 Jun 2024 13:30


Author: Rebecca Garnham
Author: Daniel Geh
Author: Ryan Nelson
Author: Erik Ramon-Gil
Author: Laura Wilson
Author: Edward N Schmidt
Author: Laura Walker
Author: Beth Adamson
Author: Adriana Buskin
Author: Anastasia C Hepburn
Author: Kirsty Hodgson
Author: Hannah Kendall
Author: Fiona M Frame
Author: Norman Maitland
Author: Kelly Coffey
Author: Douglas W Strand
Author: Craig N Robson
Author: David J Elliott
Author: Rakesh Heer
Author: Matthew Macauley
Author: Jennifer Munkley
Author: Luke Gaughan
Author: Jack Leslie
Author: Emma Scott

University Divisions

Faculty of Health Sciences and Wellbeing > School of Medicine


Sciences > Biomedical Sciences
Sciences > Health Sciences

Actions (login required)

View Item (Repository Staff Only) View Item (Repository Staff Only)