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Upregulation of GALNT7 in prostate cancer modifies O-glycosylation and promotes tumour growth

Munkley, Jennifer, Scott, Emma, Hodgson, Kirsty, Calle, Beatriz, Turner, Helen, Cheung, Kathleen, Bermudez, Abel, Marques, Fernando, Pye, Hayley, Yo, Edward Christopher, Islam, Khirul, Oo, Htoo Zarni, McClurg, Urszula L, Wilson, Laura, Thomas, Huw, Frame, Fiona M, Orozco-Moreno, Margarita, Bastian, Kayla, Arredondo, Hector M, Roustan, Chloe, Gray, Melissa Anne, Kelly, Lois, Tolson, Aaron, Mellor, Ellie, Hysenaj, Gerald, Goode, Emily Archer, Garnham, Rebecca, Duxfield, Adam, Heavey, Susan, Stopka-Farooqu, Urszula, Haider, Aiman, Freeman, Alex, Singh, Saurabh, Johnston, Edward W., Punwani, Shonit, Knight, Bridget, McCullagh, Paul, McGrath, John, Crundwell, Malcolm, Bogdan, Denisa, Harries, Lorna, Westaby, Daniel, Fowler, Gemma, Flohr, Penny, Yuan, Wei, Sharp, Adam, DeBono, Johann, Maitland, Norman, Wisnovsky, Simon, Bertozzi, Carolyn, Heer, Rakesh, Guerrero, Ramon Hurtado, Daugaard, Mads, Leivo, Janne, Whitaker, Hayley, Pitteri, Sharon, Wang, Ning, Elliott, David and Schumann, Benjamin (2022) Upregulation of GALNT7 in prostate cancer modifies O-glycosylation and promotes tumour growth. Research Square. ISSN 2693-5015

Item Type: Article


Prostate cancer is the most common cancer in men and it is estimated that over 350,000 men worldwide die of prostate cancer every year. There remains an unmet clinical need to improve how clinically significant prostate cancer is diagnosed and develop new treatments for advanced disease. Aberrant glycosylation is a hallmark of cancer implicated in tumour growth, metastasis, and immune evasion. One of the key drivers of aberrant glycosylation is the dysregulated expression of glycosylation enzymes within the cancer cell. Here, we demonstrate using multiple independent clinical cohorts that the glycosyltransferase enzyme GALNT7 is upregulated in prostate cancer tissue. We show GALNT7 can identify men with prostate cancer, using urine and blood samples, with improved diagnostic accuracy than serum PSA alone. We also show that GALNT7 levels remain high in progression to castrate-resistant disease, and using in vitro and in vivo models, reveal that GALNT7 promotes prostate tumour growth. Mechanistically, GALNT7 can modify O-glycosylation in prostate cancer cells and correlates with cell cycle and immune signalling pathways. Our study provides a new biomarker to aid the diagnosis of clinically significant disease and cements GALNT7-mediated O-glycosylation as an important driver of prostate cancer progression.

Available under License Creative Commons Attribution.

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Depositing User: Rebecca Garnham


Item ID: 17661
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ISSN: 2693-5015
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Date Deposited: 03 Jul 2024 09:06
Last Modified: 03 Jul 2024 09:15


Author: Jennifer Munkley
Author: Emma Scott
Author: Kirsty Hodgson
Author: Beatriz Calle
Author: Helen Turner
Author: Kathleen Cheung
Author: Abel Bermudez
Author: Fernando Marques
Author: Hayley Pye
Author: Edward Christopher Yo
Author: Khirul Islam
Author: Htoo Zarni Oo
Author: Urszula L McClurg
Author: Laura Wilson
Author: Huw Thomas
Author: Fiona M Frame
Author: Margarita Orozco-Moreno
Author: Kayla Bastian
Author: Hector M Arredondo
Author: Chloe Roustan
Author: Melissa Anne Gray
Author: Lois Kelly
Author: Aaron Tolson
Author: Ellie Mellor
Author: Gerald Hysenaj
Author: Emily Archer Goode
Author: Rebecca Garnham
Author: Adam Duxfield
Author: Susan Heavey
Author: Urszula Stopka-Farooqu
Author: Aiman Haider
Author: Alex Freeman
Author: Saurabh Singh
Author: Edward W. Johnston
Author: Shonit Punwani
Author: Bridget Knight
Author: Paul McCullagh
Author: John McGrath
Author: Malcolm Crundwell
Author: Denisa Bogdan
Author: Lorna Harries
Author: Daniel Westaby
Author: Gemma Fowler
Author: Penny Flohr
Author: Wei Yuan
Author: Adam Sharp
Author: Johann DeBono
Author: Norman Maitland
Author: Simon Wisnovsky
Author: Carolyn Bertozzi
Author: Rakesh Heer
Author: Ramon Hurtado Guerrero
Author: Mads Daugaard
Author: Janne Leivo
Author: Hayley Whitaker
Author: Sharon Pitteri
Author: Ning Wang
Author: David Elliott
Author: Benjamin Schumann

University Divisions

Faculty of Health Sciences and Wellbeing > School of Medicine


Sciences > Biomedical Sciences
Sciences > Health Sciences

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