Ibuprofen Loaded Avicel CL611 Pellets: Effect of Liquid Binder

Chaw, Cheng and Chia, Low (2013) Ibuprofen Loaded Avicel CL611 Pellets: Effect of Liquid Binder. In: American Association of Pharmaceutical Scientists (AAPS), 10-14 Nov 2013, Henry B Gonzalez Convention Centre, San Antonio.


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To study the effect of two liquid binders on the characteristics of pellet produced by extrusion/spheronization technique.
Eight batches of pellets containing a fixed ratio of Ibuprofen: Avicel CL611 (8:2) was produced by extrusion/spheronization
method using either water or glycerol 25% as liquid binder. Different levels of liquid binder were used (35-50 %w/w). The
pellets were characterized for particle size distribution, morphology, mechanical properties and dissolution profiles.
At the optimal levels for both liquid binders which were ranging 40- 45 % w/w, the yields of over 88% (in the sieve fractions
of 0.71-1.4 mm) and aspect ratios of less than 1.2 were obtained. The level of liquid binder required was less than those using
moderately water soluble compound. The densities of pellets were 1.2-1.3g/ml and gastric emptying rate of pellets was not
expected to be delayed. Similar surface texture and porosity (4-7 %) were observed for all pellets. Nonetheless, a lower
surface tensile strength was determined in pellets produced with glycerol 25% compared to those using water (0.48 vs. 1.07
MPa), this can affect the pellets in further processing such as tableting or coating. Glycerol is used pharmaceutically as a
wetting agent and a solvent. Low mechanical property was a consequence of the plasticizing effect of glycerol on Avicel
CL611. The pellets exhibited non- linear dissolution profiles (release faster initially) with over 75% drug being released in a
hour. The release profiles of the pellets were not affected by the type of liquid binders. Therefore, 25% glycerol was not
sufficient to alter the dissolution rate of ibuprofen. Low porosity of the pellets contributed partly to the observed outcome.
A higher level of liquid binder was required to form pellets when a hydrophobic drug such as ibuprofen was used. The level
of liquid binder was at least 1.5 times greater compared to incorporation of moderately water soluble compound. Pellets were
ductile with weaker mechanical strength when 25% glycerol was used as liquid binder which can impact on the further
processing of pellets.

Item Type: Conference or Workshop Item (Poster)
Subjects: Sciences > Pharmacy and Pharmacology
Divisions: Faculty of Health Sciences and Wellbeing
Faculty of Health Sciences and Wellbeing > School of Pharmacy and Pharmaceutical Sciences
Related URLs:
Depositing User: Hannah Dodd
Date Deposited: 14 Jul 2014 14:17
Last Modified: 18 Dec 2019 15:37
URI: http://sure.sunderland.ac.uk/id/eprint/5041
ORCID for Cheng Chaw: ORCID iD orcid.org/0000-0002-7450-4100

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