Close menu


Sunderland Repository records the research produced by the University of Sunderland including practice-based research and theses.

Effect of Crosslinking Agent Concentration on the Properties of Unmedicated Hydrogels

Wong, Rachel, Ashton, Mark and Dodou, Kalliopi (2015) Effect of Crosslinking Agent Concentration on the Properties of Unmedicated Hydrogels. Pharmaceutics, 7 (3). pp. 305-319. ISSN 1999-4923

Item Type: Article


Novel polyethylene oxide (PEO) hydrogel films were synthesized via UV crosslinking with varying concentrations of pentaerythritol tetra-acrylate (PETRA) as crosslinking agent. The aim was to study the effects of the crosslinking agent on the material properties of hydrogel films intended for dermatological applications. Fabricated film samples were characterized using swelling studies, scanning electron microscopy, tensile testing and rheometry. Films showed rapid swelling and high elasticity. The increase of PETRA concentration resulted in significant increase in the gel fraction and crosslinking density (ρc), while causing a significant decrease in the equilibrium water content (EWC), average molecular weight between crosslinks (M¯c), and mesh size (ζ) of films. From the scanning electron microscopy, cross-linked PEO hydrogel network appeared as cross-linked mesh-like structure with interconnected micropores. Rheological studies showed PEO films required a minimum of 2.5% w/w PETRA to form stable viscoelastic solid gels. Preliminary studies concluded that a minimum of 2.5% w/w PETRA is required to yield films with desirable properties for skin application.

pharmaceutics-07-00305.pdf - Published Version

Download (2MB)

More Information

Depositing User: Kalli Dodou


Item ID: 5736
Identification Number:
ISSN: 1999-4923
Official URL:

Users with ORCIDS

ORCID for Kalliopi Dodou: ORCID iD

Catalogue record

Date Deposited: 24 Sep 2015 10:36
Last Modified: 09 Oct 2020 13:47


Author: Kalliopi Dodou ORCID iD
Author: Rachel Wong
Author: Mark Ashton

University Divisions

Faculty of Health Sciences and Wellbeing
Faculty of Health Sciences and Wellbeing > School of Pharmacy and Pharmaceutical Sciences


Sciences > Pharmacy and Pharmacology

Actions (login required)

View Item (Repository Staff Only) View Item (Repository Staff Only)