Close menu


Sunderland Repository records the research produced by the University of Sunderland including practice-based research and theses.

Isoindolinone-based inhibitors of the MDM2-p53 protein-protein interaction

Hardcastle, IR, Ahmed, Shafiq, Atkins, H, Calvert, AH, Curtin, NJ, Farnie, G, Golding, BT, Griffin, RJ, Guyenne, S, Hutton, C, Kallblad, P, Kemp, SJ, Kitching, MS, Newell, DR, Norbedo, S, Northen, JS, Reid, RJ, Saravanan, K, Willems, H and Lunec, J (2005) Isoindolinone-based inhibitors of the MDM2-p53 protein-protein interaction. Bioorganic & Medicinal Chemistry Letters, 15 (5). pp. 1515-1520.

Item Type: Article


A series of 2-N-alkyl-3-aryl-3-alkoxyisoindolinones has been synthesised and evaluated as inhibitors of the MDM2-p53 interaction. The most potent compound, 3-(4-chlorophenyl)-3-(4-hydroxy-3,5-dimethoxybenzyloxy)-2-propyl-2,3-dihydroisoindol-1-one (NU8231), exhibited an IC50 of 5.3 +/- 0.9 microM in an ELISA assay, and induced p53-dependent gene transcription in a dose-dependent manner, in the SJSA human sarcoma cell line.

Full text not available from this repository.

More Information

Depositing User: Paula Normington


Item ID: 6015
Identification Number:

Users with ORCIDS

ORCID for Shafiq Ahmed: ORCID iD

Catalogue record

Date Deposited: 17 Feb 2016 12:41
Last Modified: 18 Dec 2019 15:38


Author: Shafiq Ahmed ORCID iD
Author: IR Hardcastle
Author: H Atkins
Author: AH Calvert
Author: NJ Curtin
Author: G Farnie
Author: BT Golding
Author: RJ Griffin
Author: S Guyenne
Author: C Hutton
Author: P Kallblad
Author: SJ Kemp
Author: MS Kitching
Author: DR Newell
Author: S Norbedo
Author: JS Northen
Author: RJ Reid
Author: K Saravanan
Author: H Willems
Author: J Lunec

University Divisions

Faculty of Health Sciences and Wellbeing
Faculty of Health Sciences and Wellbeing > School of Pharmacy and Pharmaceutical Sciences



Actions (login required)

View Item View Item