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Analysis of residual crosslinking agent content in UV cross-linked poly(ethylene oxide) hydrogels for dermatological application, by gas chromatography

Wong, Rachel, Ashton, Mark and Dodou, Kalliopi (2016) Analysis of residual crosslinking agent content in UV cross-linked poly(ethylene oxide) hydrogels for dermatological application, by gas chromatography. Journal of Pharmaceutical Analysis, 6 (5). pp. 307-302. ISSN 2095-1779

Item Type: Article

Abstract

Acrylates have been widely used in the synthesis of pharmaceutical polymers. The quantitation of residual acrylate monomers is vital as they are strong irritants and allergens, but after polymerization, are relatively inert, causing no irritation and allergies. Poly(ethylene oxide) (PEO) hydrogels were prepared using pentaerythritol tetra-acrylate (PETRA) as UV crosslinking agent. A simple, accurate, and robust quantitation method was developed based on gas chromatographic techniques (GC), which is suitable for routine analysis of residual PETRA monomers in these hydrogels. Unreacted PETRA was initially identified using gas chromatography–mass spectrometry (GC–MS). The quantitation of analyte was performed and validated using gas chromatography equipped with a flame ionization detector (GC–FID). A linear relationship was obtained over the range of 0.0002%–0.0450% (m/m) with a correlation coefficient (r2) greater than 0.99. The recovery (>90%), intra-day precision (%RSD <0.67), inter-day precision (%RSD <2.5%), and robustness (%RSD <1.62%) of the method were within the acceptable values. The limit of detection (LOD) and limit of quantitation (LOQ) were 0.0001% (m/m) and 0.0002% (m/m), respectively. This assay provides a simple and quick way of screening for residual acrylate monomer in hydrogels.

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Depositing User: Paula Normington

Identifiers

Item ID: 6285
Identification Number: https://doi.org/10.1016/j.jpha.2016.04.004
ISSN: 2095-1779
URI: http://sure.sunderland.ac.uk/id/eprint/6285
Official URL: http://www.sciencedirect.com/science/article/pii/S...

Users with ORCIDS

ORCID for Kalliopi Dodou: ORCID iD orcid.org/0000-0002-2822-3543

Catalogue record

Date Deposited: 10 May 2016 14:07
Last Modified: 18 Dec 2019 15:39

Contributors

Author: Kalliopi Dodou ORCID iD
Author: Rachel Wong
Author: Mark Ashton

University Divisions

Faculty of Health Sciences and Wellbeing
Faculty of Health Sciences and Wellbeing > School of Pharmacy and Pharmaceutical Sciences

Subjects

Sciences

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